引用本文:
Jin Lan ZHANG, Tong Hui ZHOU. A New Method of Separation of Four Benzodiazepines by RP-CEC[J]. Chinese Chemical Letters,
2004, 15(8): 935-938.
Citation: Jin Lan ZHANG, Tong Hui ZHOU. A New Method of Separation of Four Benzodiazepines by RP-CEC[J]. Chinese Chemical Letters, 2004, 15(8): 935-938.
Citation: Jin Lan ZHANG, Tong Hui ZHOU. A New Method of Separation of Four Benzodiazepines by RP-CEC[J]. Chinese Chemical Letters, 2004, 15(8): 935-938.
A New Method of Separation of Four Benzodiazepines by RP-CEC
摘要:
A new method to separate diazepam, nitrazepam, estazolam, alprazolam was established on both C18 and C8 CEC columns.The influence of separation voltage, Tris concentration, column temperature and the percentage of acetonitrile on the resolution and retention behavior of four benzodiazepines was investigated.The results showed that the percentage of acetonitrile had the largest effect on the resolution and retention behavior of the four benzodiazepines.Other separation conditions had also effects on the resolution and retention behavior, but smaller than the concentration of acetonitrile.Optimum separation conditions were obtained to separate four benzodiazepines on C18 and C8 CEC columns.
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关键词:
- Capillary electrochromatography
- / diazepam
- / nitrazepam
- / estazolam
- / alprazolam
English
A New Method of Separation of Four Benzodiazepines by RP-CEC
Abstract:
A new method to separate diazepam, nitrazepam, estazolam, alprazolam was established on both C18 and C8 CEC columns.The influence of separation voltage, Tris concentration, column temperature and the percentage of acetonitrile on the resolution and retention behavior of four benzodiazepines was investigated.The results showed that the percentage of acetonitrile had the largest effect on the resolution and retention behavior of the four benzodiazepines.Other separation conditions had also effects on the resolution and retention behavior, but smaller than the concentration of acetonitrile.Optimum separation conditions were obtained to separate four benzodiazepines on C18 and C8 CEC columns.
-
Key words:
- Capillary electrochromatography
- / diazepam
- / nitrazepam
- / estazolam
- / alprazolam
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