引用本文:
Juan Shen, Jing Bo Shi, Fei Hu Chen, Yuan Wang, Jing Jing Ruan, Yan Huang. Synthesis and anti-tumor activity of all-trans retinoic acid derivatives[J]. Chinese Chemical Letters,
2009, 20(7): 809-811.
doi:
10.1016/j.cclet.2009.01.041
Citation: Juan Shen, Jing Bo Shi, Fei Hu Chen, Yuan Wang, Jing Jing Ruan, Yan Huang. Synthesis and anti-tumor activity of all-trans retinoic acid derivatives[J]. Chinese Chemical Letters, 2009, 20(7): 809-811. doi: 10.1016/j.cclet.2009.01.041
Citation: Juan Shen, Jing Bo Shi, Fei Hu Chen, Yuan Wang, Jing Jing Ruan, Yan Huang. Synthesis and anti-tumor activity of all-trans retinoic acid derivatives[J]. Chinese Chemical Letters, 2009, 20(7): 809-811. doi: 10.1016/j.cclet.2009.01.041
Synthesis and anti-tumor activity of all-trans retinoic acid derivatives
摘要:
A series of retinoate and retinamide derivatives were designed, synthesized, and their anti-tumor activities were investigated in NB4 by MTT and flow cytometry assays (FCM). All compounds showed cytotoxicity, especially compounds 1a and 1d exhibited a higher cytotoxicity than other derivatives and all-trans retinoic acid (ATRA). Furthermore, compound 1d could induce NB4 cell lines differentiation efficiently.
English
Synthesis and anti-tumor activity of all-trans retinoic acid derivatives
Abstract:
A series of retinoate and retinamide derivatives were designed, synthesized, and their anti-tumor activities were investigated in NB4 by MTT and flow cytometry assays (FCM). All compounds showed cytotoxicity, especially compounds 1a and 1d exhibited a higher cytotoxicity than other derivatives and all-trans retinoic acid (ATRA). Furthermore, compound 1d could induce NB4 cell lines differentiation efficiently.
-
Key words:
- All-trans retinoic acid
- / Synthesis
- / Cell differentiation
- / NB4 cell lines
扫一扫看文章
计量
- PDF下载量: 5
- 文章访问数: 1704
- HTML全文浏览量: 63
下载:
