Conjugation of Chitooligosaccharide-5-fluorouracil with Bovine Serum Albumin

Rong Min WANG ,  Jing Feng SONG ,  Yu Feng HE ,  Juan Juan MAO ,  Yan LI

引用本文: Rong Min WANG,  Jing Feng SONG,  Yu Feng HE,  Juan Juan MAO,  Yan LI. Conjugation of Chitooligosaccharide-5-fluorouracil with Bovine Serum Albumin[J]. Chinese Chemical Letters, 2006, 17(11): 1495-1498. shu
Citation:  Rong Min WANG,  Jing Feng SONG,  Yu Feng HE,  Juan Juan MAO,  Yan LI. Conjugation of Chitooligosaccharide-5-fluorouracil with Bovine Serum Albumin[J]. Chinese Chemical Letters, 2006, 17(11): 1495-1498. shu

Conjugation of Chitooligosaccharide-5-fluorouracil with Bovine Serum Albumin

  • 基金项目:

    The project was supported by the National Natural Science Foundation of China (No.20274034) and the Natural Science Foundation of Gansu Province (3ZS061-A25-036).

摘要: The interaction between chitooligosaccharide-5-fluorouracil (COS-5FU) and bovine serum albumin (BSA) was studied by fluorescence spectroscopy. It was found that an energy transfer between COS-5FU and BSA had been occurred. The binding constants were calculated, k298k=1.175×10-4L·mol-1.Based on the mechanism of energy transfer of dipole interaction between the donor and acceptor, the distance between BSA and COS-5FU was determined.

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  • 收稿日期:  2006-09-04
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