引用本文:
Ming Liang Ma, Xiao Yan Li, Ke Wen, Yahu A. Liu. 5-Hexylidene-4-propylamino-1,5-dihydroimidazol-2-one formed from Cu-catalyzed oxidation with implication for the structure of a His-Lys cross-link[J]. Chinese Chemical Letters,
2007, 18(9): 1025-1028.
doi:
10.1016/j.cclet.2007.06.025
Citation: Ming Liang Ma, Xiao Yan Li, Ke Wen, Yahu A. Liu. 5-Hexylidene-4-propylamino-1,5-dihydroimidazol-2-one formed from Cu-catalyzed oxidation with implication for the structure of a His-Lys cross-link[J]. Chinese Chemical Letters, 2007, 18(9): 1025-1028. doi: 10.1016/j.cclet.2007.06.025
Citation: Ming Liang Ma, Xiao Yan Li, Ke Wen, Yahu A. Liu. 5-Hexylidene-4-propylamino-1,5-dihydroimidazol-2-one formed from Cu-catalyzed oxidation with implication for the structure of a His-Lys cross-link[J]. Chinese Chemical Letters, 2007, 18(9): 1025-1028. doi: 10.1016/j.cclet.2007.06.025
5-Hexylidene-4-propylamino-1,5-dihydroimidazol-2-one formed from Cu-catalyzed oxidation with implication for the structure of a His-Lys cross-link
摘要:
Cu-catalyzed oxidation of 5-hexyl-1, 3-dihydroimidazo-2-one (1) in the presence of propylamine, as surrogates for the oxidized His side chain and Lys side chain, was investigated. 5-Hexylidene-4-propylamino-1, 5-dihydroimidazol-2-one (2), a model His-Lys cross-link product, was isolated and structurally characterized by NMR and mass spectrometry.
English
5-Hexylidene-4-propylamino-1,5-dihydroimidazol-2-one formed from Cu-catalyzed oxidation with implication for the structure of a His-Lys cross-link
Abstract:
Cu-catalyzed oxidation of 5-hexyl-1, 3-dihydroimidazo-2-one (1) in the presence of propylamine, as surrogates for the oxidized His side chain and Lys side chain, was investigated. 5-Hexylidene-4-propylamino-1, 5-dihydroimidazol-2-one (2), a model His-Lys cross-link product, was isolated and structurally characterized by NMR and mass spectrometry.
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Key words:
- His-Lys cross-link
- / Metal-catalyzed protein oxidation
- / Oxidative stress
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