引用本文:
Bao Hua ZHU, Hong YAN, Lai Bin LUO, Ze Hua LIU, Hui Lan CHEN. PREPARATION AND CHARACTERIZATION OF A NEW COENZYME B12 ANALOGUE CONTAINING 2',3'-DIDEOXYURIDINE[J]. Chinese Chemical Letters,
1996, 7(6): 503-504.
Citation: Bao Hua ZHU, Hong YAN, Lai Bin LUO, Ze Hua LIU, Hui Lan CHEN. PREPARATION AND CHARACTERIZATION OF A NEW COENZYME B12 ANALOGUE CONTAINING 2',3'-DIDEOXYURIDINE[J]. Chinese Chemical Letters, 1996, 7(6): 503-504.
Citation: Bao Hua ZHU, Hong YAN, Lai Bin LUO, Ze Hua LIU, Hui Lan CHEN. PREPARATION AND CHARACTERIZATION OF A NEW COENZYME B12 ANALOGUE CONTAINING 2',3'-DIDEOXYURIDINE[J]. Chinese Chemical Letters, 1996, 7(6): 503-504.
PREPARATION AND CHARACTERIZATION OF A NEW COENZYME B12 ANALOGUE CONTAINING 2',3'-DIDEOXYURIDINE
摘要:
A new kind of coenzyme B12 analogue 2',3',5'-trideoxyuridinyl-cobalamin (ddUCbl) was first synthesized by an improved method in which 5'-O-toluenesulfonyl-2',3'-dideoxyuridine was first transformed into 5'-iodo-2',3'-dideoxyuridine and then reacted with reduced hydroxocobalamin.The new analogue was characterized by UV-vis and 1HNMR spectroscopy.
English
PREPARATION AND CHARACTERIZATION OF A NEW COENZYME B12 ANALOGUE CONTAINING 2',3'-DIDEOXYURIDINE
Abstract:
A new kind of coenzyme B12 analogue 2',3',5'-trideoxyuridinyl-cobalamin (ddUCbl) was first synthesized by an improved method in which 5'-O-toluenesulfonyl-2',3'-dideoxyuridine was first transformed into 5'-iodo-2',3'-dideoxyuridine and then reacted with reduced hydroxocobalamin.The new analogue was characterized by UV-vis and 1HNMR spectroscopy.
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