引用本文:
Jian Jun Xue, Xiao Ming Yu. Selective 3- and 6-OH modification of (-)-clausenamide[J]. Chinese Chemical Letters,
2011, 22(7): 671-764.
doi:
10.1016/j.cclet.2011.01.026
Citation: Jian Jun Xue, Xiao Ming Yu. Selective 3- and 6-OH modification of (-)-clausenamide[J]. Chinese Chemical Letters, 2011, 22(7): 671-764. doi: 10.1016/j.cclet.2011.01.026
Citation: Jian Jun Xue, Xiao Ming Yu. Selective 3- and 6-OH modification of (-)-clausenamide[J]. Chinese Chemical Letters, 2011, 22(7): 671-764. doi: 10.1016/j.cclet.2011.01.026
Selective 3- and 6-OH modification of (-)-clausenamide
摘要:
(-)-Clausenamide is a drug candidate under Phase I clinical trial for treatment of Alzheimer's disease (AD). In order to elucidate the substituent related structure-activity relationship, six one-substituent modified (-)-clausenamide analogues were designed, and four of them, namely 3-0-methyl, 6-0-methyl, 3-des-hydroxyl and 6-des-hydroxyl analogues were prepared by selective 3- and 6- OH modification of (-)-clausenamide.
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关键词:
- (-)-Clausenamide
- / Derivatives
- / Synthesis
- / Alzheimer's diseas
English
Selective 3- and 6-OH modification of (-)-clausenamide
Abstract:
(-)-Clausenamide is a drug candidate under Phase I clinical trial for treatment of Alzheimer's disease (AD). In order to elucidate the substituent related structure-activity relationship, six one-substituent modified (-)-clausenamide analogues were designed, and four of them, namely 3-0-methyl, 6-0-methyl, 3-des-hydroxyl and 6-des-hydroxyl analogues were prepared by selective 3- and 6- OH modification of (-)-clausenamide.
-
Key words:
- (-)-Clausenamide
- / Derivatives
- / Synthesis
- / Alzheimer's diseas
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