引用本文:
Wei Hong, James Dowden. Facile synthesis of N-6 adenosine modified analogue toward S-adenosyl methionine derived probe for protein arginine methyltransferases[J]. Chinese Chemical Letters,
2011, 22(12): 1439-1442.
doi:
10.1016/j.cclet.2011.09.007
Citation: Wei Hong, James Dowden. Facile synthesis of N-6 adenosine modified analogue toward S-adenosyl methionine derived probe for protein arginine methyltransferases[J]. Chinese Chemical Letters, 2011, 22(12): 1439-1442. doi: 10.1016/j.cclet.2011.09.007
Citation: Wei Hong, James Dowden. Facile synthesis of N-6 adenosine modified analogue toward S-adenosyl methionine derived probe for protein arginine methyltransferases[J]. Chinese Chemical Letters, 2011, 22(12): 1439-1442. doi: 10.1016/j.cclet.2011.09.007
Facile synthesis of N-6 adenosine modified analogue toward S-adenosyl methionine derived probe for protein arginine methyltransferases
摘要:
Chemically modified cellular co-factors that provide function, such as immobilization or incorporation of fluorescent dyes, are valuable probes of biological activity. A convenient route to obtain S-adenosyl methionine (AdoMet) analogues modified at N-6 adenosine to feature a linker terminating in azide functionality is described herein. Subsequent decoration of such AdoMet analogues with guanidinium terminated linkers leads to novel potential bisubstrate inhibitors for protein arginine methyltransferases, PRMTs.
English
Facile synthesis of N-6 adenosine modified analogue toward S-adenosyl methionine derived probe for protein arginine methyltransferases
Abstract:
Chemically modified cellular co-factors that provide function, such as immobilization or incorporation of fluorescent dyes, are valuable probes of biological activity. A convenient route to obtain S-adenosyl methionine (AdoMet) analogues modified at N-6 adenosine to feature a linker terminating in azide functionality is described herein. Subsequent decoration of such AdoMet analogues with guanidinium terminated linkers leads to novel potential bisubstrate inhibitors for protein arginine methyltransferases, PRMTs.
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Key words:
- Protein arginine methyltransferases
- / S-Adenosyl methionine
- / Nucleosides
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