引用本文:
Zi Cheng LI, Ning JIANG, Shu Hua CHEN, Ding LU. A New Method for Synthesis of Methyl 3-Azido-3-deoxy-2-O-mesyl-5-O-benzoylxylofuranoside[J]. Chinese Chemical Letters,
2002, 13(3): 195-198.
Citation: Zi Cheng LI, Ning JIANG, Shu Hua CHEN, Ding LU. A New Method for Synthesis of Methyl 3-Azido-3-deoxy-2-O-mesyl-5-O-benzoylxylofuranoside[J]. Chinese Chemical Letters, 2002, 13(3): 195-198.
Citation: Zi Cheng LI, Ning JIANG, Shu Hua CHEN, Ding LU. A New Method for Synthesis of Methyl 3-Azido-3-deoxy-2-O-mesyl-5-O-benzoylxylofuranoside[J]. Chinese Chemical Letters, 2002, 13(3): 195-198.
A New Method for Synthesis of Methyl 3-Azido-3-deoxy-2-O-mesyl-5-O-benzoylxylofuranoside
摘要:
A new method for synthesis of 3-azido-3-deoxyxylofuranoside was described. D-ribose was methylated, then treated with methanesulfonyl chloride to give Ⅱ. Ⅱ was selectively replaced by benzoate at the 5-position to give Ⅲ. All these processes gave good yields. Ⅲ was treated with sodium azide to afford Ⅳ, whose structure was determined by 1H NMR and 13C NMR.
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关键词:
- Xylose derivative
- / nucleoside
- / synthesis
English
A New Method for Synthesis of Methyl 3-Azido-3-deoxy-2-O-mesyl-5-O-benzoylxylofuranoside
Abstract:
A new method for synthesis of 3-azido-3-deoxyxylofuranoside was described. D-ribose was methylated, then treated with methanesulfonyl chloride to give Ⅱ. Ⅱ was selectively replaced by benzoate at the 5-position to give Ⅲ. All these processes gave good yields. Ⅲ was treated with sodium azide to afford Ⅳ, whose structure was determined by 1H NMR and 13C NMR.
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Key words:
- Xylose derivative
- / nucleoside
- / synthesis
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