引用本文:
程青芳, 许兴友, 王启发, 张君磊, 张莉, 杨绪杰. 水介质中微波促进一锅法合成吡喃并[2,3-d]嘧啶衍生物[J]. 应用化学,
2010, 27(6): 673-676.
doi:
10.3724/SP.J.1095.2010.90533
Citation: CHENG Qing-Fang, XU Xing-You, WANG Qi-Fa, ZHANG Jun-Lei, ZHANG Li, YANG Xu-Jie. One-Pot Synthesis of Pyrano[2,3-d] pyrimidine Derivatives in Aqueous Media under Microwave Irradiation[J]. Chinese Journal of Applied Chemistry, 2010, 27(6): 673-676. doi: 10.3724/SP.J.1095.2010.90533
Citation: CHENG Qing-Fang, XU Xing-You, WANG Qi-Fa, ZHANG Jun-Lei, ZHANG Li, YANG Xu-Jie. One-Pot Synthesis of Pyrano[2,3-d] pyrimidine Derivatives in Aqueous Media under Microwave Irradiation[J]. Chinese Journal of Applied Chemistry, 2010, 27(6): 673-676. doi: 10.3724/SP.J.1095.2010.90533
水介质中微波促进一锅法合成吡喃并[2,3-d]嘧啶衍生物
English
One-Pot Synthesis of Pyrano[2,3-d] pyrimidine Derivatives in Aqueous Media under Microwave Irradiation
Abstract:
Nine 7-amino-6-cyano-5-aryl-5H-pyrano[2,3-d] pyrimidine-2,4(1H,3H)-diones were synthesized via the one-pot three-component condensation reactions of aromatic aldehydes,malononitrile and barbituric acid in aqueous media without catalyst under the irradiation of microwave. The reactants were mixed in an equal molar ratio,and exposed to MW irradiation for 5~15 min,and the yields were 80%~92%. This method avoided the long reaction time of usual synthesis route and the troubles of isolation the intermediate and minimized the environmental pollution. The structures of the products were characterized by IR,1H NMR spectroscopies and elemental analysis.
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Key words:
- pyrano[d] pyrimidine
- / microwave irradiation
- / one-pot synthesis
- / aqueous media
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