引用本文:
Wei LI, Wen YUAN, Wei Jun JIN, Chuan DONG. Study on the Interaction of Mitomycin C with ct-DNA by Pd-Porphin Room Temperature Phosphorescence Probe[J]. Chinese Chemical Letters,
2001, 12(12): 1089-1092.
Citation: Wei LI, Wen YUAN, Wei Jun JIN, Chuan DONG. Study on the Interaction of Mitomycin C with ct-DNA by Pd-Porphin Room Temperature Phosphorescence Probe[J]. Chinese Chemical Letters, 2001, 12(12): 1089-1092.
Citation: Wei LI, Wen YUAN, Wei Jun JIN, Chuan DONG. Study on the Interaction of Mitomycin C with ct-DNA by Pd-Porphin Room Temperature Phosphorescence Probe[J]. Chinese Chemical Letters, 2001, 12(12): 1089-1092.
Study on the Interaction of Mitomycin C with ct-DNA by Pd-Porphin Room Temperature Phosphorescence Probe
摘要:
Anticancer drug Mitomycin C (MMC) quenches remarkably phosphorescence and reduces lifetime of phosphorescence probe, Pd-meso-tetrakis-(4-trimethylaminophenyl) porphin (Pd-TAPP), in the presence of calf thymus DNA. These results may be attributed to the site competition of MMC with the probe and electron transfer between MMC and probe. MMC also increases polarization degree of the probe by covalent drug-DNA or DNA-drug-DNA crosslinking.
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关键词:
- Phosphorescence probe
- / mitomycin C
- / ct-DNA
English
Study on the Interaction of Mitomycin C with ct-DNA by Pd-Porphin Room Temperature Phosphorescence Probe
Abstract:
Anticancer drug Mitomycin C (MMC) quenches remarkably phosphorescence and reduces lifetime of phosphorescence probe, Pd-meso-tetrakis-(4-trimethylaminophenyl) porphin (Pd-TAPP), in the presence of calf thymus DNA. These results may be attributed to the site competition of MMC with the probe and electron transfer between MMC and probe. MMC also increases polarization degree of the probe by covalent drug-DNA or DNA-drug-DNA crosslinking.
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Key words:
- Phosphorescence probe
- / mitomycin C
- / ct-DNA
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