引用本文:
石敬民, 廖代正, 程鹏, 缪明明, 姜宗慧, 刘永江, 王耕霖. 4-硝基邻苯二甲酸根桥联双核钴(Ⅱ)配合物的合成、磁性及抗癌活性[J]. 应用化学,
1996, 13(4): 86-88.
Citation: Shi Jingmin, Liao Daizheng, Cheng Peng, Miao Mingming, Jiang Zonghui, Liu Yongjiang, Wang Genglin. Synthesis、Magnetism and Cancer-Inhibiting Activity of μ-4-Nitrophthalato Binuclear Cobalt(Ⅱ) Complexes[J]. Chinese Journal of Applied Chemistry, 1996, 13(4): 86-88.
Citation: Shi Jingmin, Liao Daizheng, Cheng Peng, Miao Mingming, Jiang Zonghui, Liu Yongjiang, Wang Genglin. Synthesis、Magnetism and Cancer-Inhibiting Activity of μ-4-Nitrophthalato Binuclear Cobalt(Ⅱ) Complexes[J]. Chinese Journal of Applied Chemistry, 1996, 13(4): 86-88.
4-硝基邻苯二甲酸根桥联双核钴(Ⅱ)配合物的合成、磁性及抗癌活性
English
Synthesis、Magnetism and Cancer-Inhibiting Activity of μ-4-Nitrophthalato Binuclear Cobalt(Ⅱ) Complexes
Abstract:
Two new novel binuclear cobalt (Ⅱ) complexes, namely,[Co2(4PT)(Phen)4](ClO4)2·3H2O (complex 1) and[Co2(4PT)(NPhen)4] (ClO4)2·2H2O (complex 2) (4PT=4-nitrophthalato, Phen=l,10-phenanthroline, NPhen=5-nitro-1,10-phenanthroline) have been synthesized. The complexes were characterized by elemental analysis, IR, UV-Vis spectra and electronic conductance. The variable-temperature magnetic susceptibility of the complexes was measured over 77~300 K. The data were analyzed by using the magnetic susceptibility equation based on Heisenberg spin-exchange operator, and the exchange integrals for complex 1 and complex 2 were found 2J=-8.6 cm-1 and 2J=-4.3 cm-1,respectively. Experiments of inhibiting human leukemia cell, stomach cancer cell and carcinoma of nasopharyngeal cancer cell in vitro were made,and found that the complexes exhibited a relatively strong function of inhibiting these three kinds of cancer cells.
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Key words:
- nitrophthalate
- / binuclear Co(Ⅱ) complex
- / magnetism
- / bioactivity
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