引用本文:
陶志福, 钱旭红, 唐军, 陈馥衡. 2H-4,9-二甲基呋喃并[2',3':5,6]萘并[1,2-b]吡喃-2-酮的合成、光谱及DNA嵌入活性[J]. 应用化学,
1996, 13(4): 34-37.
Citation: Tao Zhifu, Qian Xuhong, Tang Jun, Chen Fuheng. Synthesis, Spectra and DNA Intercalation of 2H-4, 9-Dimethylfuro[2', 3': 5, 6] naphtho[1, 2-b] pyron-2-one[J]. Chinese Journal of Applied Chemistry, 1996, 13(4): 34-37.
Citation: Tao Zhifu, Qian Xuhong, Tang Jun, Chen Fuheng. Synthesis, Spectra and DNA Intercalation of 2H-4, 9-Dimethylfuro[2', 3': 5, 6] naphtho[1, 2-b] pyron-2-one[J]. Chinese Journal of Applied Chemistry, 1996, 13(4): 34-37.
2H-4,9-二甲基呋喃并[2',3':5,6]萘并[1,2-b]吡喃-2-酮的合成、光谱及DNA嵌入活性
English
Synthesis, Spectra and DNA Intercalation of 2H-4, 9-Dimethylfuro[2', 3': 5, 6] naphtho[1, 2-b] pyron-2-one
Abstract:
The title compound was synthesized by three methods from naphthopyrone. The structures of this compound and its precursors were fully characterized by 1H NMR, MS, IR and elemental analysis.Its DNA-intercalative activity was investigated in DMSO-Tris HCl system by fluorescence quenching technique and the apparent Scatchard binding constant was estimated. Results showed that it efficiently intercalated into DNA.The spectral properties and DNA-intercalative activity have been compared with those of its analogues.
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Key words:
- naphthopyrones
- / DNA intercalation activity
- / synthesis
- / spectrum
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