引用本文:
陈韶蕊, 马吉海, 周雪琴, 刘东志. 合成1,2-环十二二酮的新方法[J]. 应用化学,
2009, 26(11): 1374-1376.
Citation: CHEN Shao-Rui, MA Ji-Hai, ZHOU Xue-Qin, LIU Dong-Zhi. A Novel Synthetic Method of 1,2-Cyclododecandione[J]. Chinese Journal of Applied Chemistry, 2009, 26(11): 1374-1376.
Citation: CHEN Shao-Rui, MA Ji-Hai, ZHOU Xue-Qin, LIU Dong-Zhi. A Novel Synthetic Method of 1,2-Cyclododecandione[J]. Chinese Journal of Applied Chemistry, 2009, 26(11): 1374-1376.
合成1,2-环十二二酮的新方法
English
A Novel Synthetic Method of 1,2-Cyclododecandione
Abstract:
1,2-Cyclododecandione(4) was synthesized from dodecanedioic acid via esterification,acyloin condensation,oxidation in an overall yield of 43.1%.Reaction of dodecanedioic acid with methanol gave dodecanedioic acid dimethyl ester(2) with a yield of 86.5%.Compound 3 was obtained from compound 2 through acyloin condensation and the yield reached up to 63.1%,which was oxidized to compound 4 by bromine water as the oxidation reagent with a yield of 79%.The target compound was a light yellow crystal and was characterized by means of IR,1H NMR and 13C NMR.
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Key words:
- dodecanedioic acid
- / acyloin condensation
- / cyclododecandione
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