引用本文:
赵微微, 董叶叶, 李宗孝. 紫杉醇在二甲基亚砜中的溶解行为[J]. 应用化学,
2011, 28(4): 438-442.
doi:
10.3724/SP.J.1095.2011.00343
Citation: ZHAO Weiwei, DONG Yeye, LI Zongxiao. Dissolution Properties of Paclitaxel in Dimethylsulfoxide[J]. Chinese Journal of Applied Chemistry, 2011, 28(4): 438-442. doi: 10.3724/SP.J.1095.2011.00343
Citation: ZHAO Weiwei, DONG Yeye, LI Zongxiao. Dissolution Properties of Paclitaxel in Dimethylsulfoxide[J]. Chinese Journal of Applied Chemistry, 2011, 28(4): 438-442. doi: 10.3724/SP.J.1095.2011.00343
紫杉醇在二甲基亚砜中的溶解行为
English
Dissolution Properties of Paclitaxel in Dimethylsulfoxide
Abstract:
The enthalpies of dissolution of paclitaxel in dimethylsulfoxide(DMSO) was reported.The differential enthalpy(ΔdifHm) and the molar enthalpy(ΔsolHm) were determined,and the relationship between the amount of heat released and the amount of solute was also established.The corresponding kinetic equation that describes the dissolution process is (da)/(dt)=2.92×10-4×(1-a)1.00,and the kinetic parameters are obtained as follows:t1/2=50.43 min,ΔsolHm=32.67 kJ/mol,and ΔsolSm=-204.93 J/(mol·K).The result not only provides a simple method for the determination of the half-life for drugs,but it can also offer a theoretical reference for the clinical application of paclitaxel using microcalorimeter.
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Key words:
- thermodynamics
- / kinetics
- / dissolution heat
- / paclitaxel
- / dimethylsulfoxide
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