引用本文:
王茹林, 姜鸿彦, 秦姝竹, 王鹏. β-环糊精对氯诺昔康的包合作用[J]. 应用化学,
2011, 28(4): 421-425.
doi:
10.3724/SP.J.1095.2011.00358
Citation: WANG Rulin, JIANG Hongyan, QIN Shuzhu, WANG Peng. Inclusions of Lornoxicam by β-Cyclodextrin and Its Derivatives[J]. Chinese Journal of Applied Chemistry, 2011, 28(4): 421-425. doi: 10.3724/SP.J.1095.2011.00358
Citation: WANG Rulin, JIANG Hongyan, QIN Shuzhu, WANG Peng. Inclusions of Lornoxicam by β-Cyclodextrin and Its Derivatives[J]. Chinese Journal of Applied Chemistry, 2011, 28(4): 421-425. doi: 10.3724/SP.J.1095.2011.00358
β-环糊精对氯诺昔康的包合作用
English
Inclusions of Lornoxicam by β-Cyclodextrin and Its Derivatives
Abstract:
The inclusions of lornoxicam(LX) by β-cyclodextrin(β-CD),hydroxypropyl-β-cyclodextrin(HP-β-CD),and sulfobutyl ether-β-cyclodextrin(SBE-β-CD) were studied by fluorescence spectroscopy,differential scanning calorimetry(DSC) and NMR at different pH and temperature.The results showed that the 1:1 inclusion compounds were formed between lornoxicam and CDs.Based on the formation constants,the interactions between lornoxicam and the three CDs follow an order of SBE-β-CD >HP-β-CD >β-CD.
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Key words:
- lornoxicam
- / β-cyclodextrin
- / fluorescence spectroscopy
- / DSC
- / NMR
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