引用本文:
李勤, 周尚, 杨季冬. 氟喹诺酮类抗生素与磷钨酸体系的共振瑞利散射光谱研究及其分析应用[J]. 应用化学,
2011, 28(1): 107-112.
doi:
10.3724/SP.J.1095.2011.00195
Citation: LI Qin, ZHOU Shang, YANG Jidong. Study on Resonance Rayleigh Scattering Spectra of Phosphowolframic Acid and Fluoroquinolone Antibiotics System and Their Analytical Application[J]. Chinese Journal of Applied Chemistry, 2011, 28(1): 107-112. doi: 10.3724/SP.J.1095.2011.00195
Citation: LI Qin, ZHOU Shang, YANG Jidong. Study on Resonance Rayleigh Scattering Spectra of Phosphowolframic Acid and Fluoroquinolone Antibiotics System and Their Analytical Application[J]. Chinese Journal of Applied Chemistry, 2011, 28(1): 107-112. doi: 10.3724/SP.J.1095.2011.00195
氟喹诺酮类抗生素与磷钨酸体系的共振瑞利散射光谱研究及其分析应用
摘要:
在5.0mol/L的HCl缓冲介质中,磷钨酸(Pwa)与莫西沙星(MXFX)和加替沙星(GTF)等氟喹诺酮类抗生素(FLQs)相互作用形成摩尔比1:1离子缔合物,导致体系的共振瑞利散射(RRS)显著增强并出现新的RRS光谱。MXFX和GTF的反应产物具有相似的光谱特征,最大散射波长位于320nm附近,且药物浓度与散射增强(ΔI)成正比,2种氟喹诺酮类药物的线性范围分别为0.025~6.0mg/L(MXFX)和0.023~9.0mg/L(GTF)。据此可建立用于测定氟喹诺酮类药物的简捷快速灵敏的新方法,方法用于胶囊和人尿液中的FLQs测定并取得满意结果。并对反应机理和RRS增强的原因进行了讨论。
English
Study on Resonance Rayleigh Scattering Spectra of Phosphowolframic Acid and Fluoroquinolone Antibiotics System and Their Analytical Application
Abstract:
In 5.0 mol/L HCl buffer solution, phosphowolframic acid (Pwa) could react with moxifloxacin (MXFX) and gatifloxacin (GTF) fluoroquinolone antibiotics (FLQs) to form 1:1 ion-associated complexes respectively. The reactions resulted in great enhancement of resonance Rayleigh scattering(RRS) and new RRS bands appear. The reaction products of the two drugs had similar spectral characteristics, and the maximum RRS wavelength was located at 320 nm. The intensities of RRS are proportional to the concentration of antibiotics, the linearity ranges of two fluoroquinolone antibiotics are 0.025~6.0 mg/L (MXFX) and 0.023~9.0 mg/L(GTF), respectively. Therefore, a new method for determination of the drugs could be developed and applied to the determination of FLQs in capsules and human urine samples. The reaction mechanism and the reasons for RRS enhancement of the system were investigated.
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