引用本文:
姜忠义, 贾琦鹏, 刘家祺, 陈洪钫. 多相酶膜反应器合成生物活性二肽[J]. 应用化学,
2001, 18(1): 56-58.
Citation: JIANG Zhong-Yi, JIA Qi-Peng, LIU Jia-Qi, CHEN Hong-Fang. Synthesis of Biologically Active Dipeptide in a Multiphase Enzyme Membrane Reactor[J]. Chinese Journal of Applied Chemistry, 2001, 18(1): 56-58.
Citation: JIANG Zhong-Yi, JIA Qi-Peng, LIU Jia-Qi, CHEN Hong-Fang. Synthesis of Biologically Active Dipeptide in a Multiphase Enzyme Membrane Reactor[J]. Chinese Journal of Applied Chemistry, 2001, 18(1): 56-58.
多相酶膜反应器合成生物活性二肽
English
Synthesis of Biologically Active Dipeptide in a Multiphase Enzyme Membrane Reactor
Abstract:
A multiphase enzyme membrane reactor using aqueous-organic biphase instead of water phase alone as the reaction medium was employed to investigate the lipase-catalyzed synthesis of bioactive dipeptides. The medium effect on dipeptide yield was first studied. When N-acetyl-L-phenylalanine ethyl ester(APEE) was used as a carboxyl component, the reactivity order of amino acid amides was found to be L-Leu-NH2 >L-Val-NH2 >L-Ala-NH2 >L-Gly-NH2. The didpetide, N-Ac-L-Phe-L-Leu NH2, could be synthesized in the multiphase enzyme membrane reactor in a high yield and purity due to the simultaneous separation and reaction.
-
Key words:
- lipase
- / multiphase membrane reactor
- / synthesis
-
-
扫一扫看文章
计量
- PDF下载量: 1
- 文章访问数: 956
- HTML全文浏览量: 121
下载:
