引用本文:
鲁桂, 姚克敏, 张肇英, 沈联芳. 镧系与直链醚-组氨酸Schiff碱新配合物的合成、波谱与生物活性[J]. 应用化学,
2001, 18(1): 1-4.
Citation: LU Gui, YAO Ke-Min, ZHANG Zhao-Ying, SHEN Lian-Fang. Studies on Synthesis,Magnetic Resonance and Biological Activity of Lanthanide Complexes with Noncyclic Polyether-Histidine Schiff Base[J]. Chinese Journal of Applied Chemistry, 2001, 18(1): 1-4.
Citation: LU Gui, YAO Ke-Min, ZHANG Zhao-Ying, SHEN Lian-Fang. Studies on Synthesis,Magnetic Resonance and Biological Activity of Lanthanide Complexes with Noncyclic Polyether-Histidine Schiff Base[J]. Chinese Journal of Applied Chemistry, 2001, 18(1): 1-4.
镧系与直链醚-组氨酸Schiff碱新配合物的合成、波谱与生物活性
摘要:
合成了直链醚-组氨酸Schiff碱(四甘醇醛缩双组氨酸Schiff碱)及其稀土配合物,以元素分析、红外光谱、热重、磁化率等确定配合物组成为Ln3(H2L)2(NO3)9(Ln=La,Nd,Gd,Er,Yb;L=C20H26N6O7).采用交叉极化结合魔角旋转技术(CP/MAS)和消除旋转边带技术(TOSS),获得固体高分辨13C NMR谱,见到-COO-的13C谱峰分裂等新信息.结合液体1H NMR谱等,对L-组氨酸中咪唑基的配位进行了研究.以EPR波谱探讨了配合物的晶体场强等特性.观察到Er配合物对超氧阴离子自由基的清除有一定效果.
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关键词:
- 稀土Schiff碱配合物
- / 固体高分辨13C NMR
- / EPR波谱
English
Studies on Synthesis,Magnetic Resonance and Biological Activity of Lanthanide Complexes with Noncyclic Polyether-Histidine Schiff Base
Abstract:
Five lanthanide complexes with tetraglycol aldehyde bis-histidine Schiff base were synthesized and characterized by elemental analysis, IR spectrometry, TG-DTA and magnetic susceptibility as Ln3(H2L)2(NO3)9(Ln=La,Nd,Gd,Er,Yb; L=C20H26N6O7). The obtained complexes were investigated in detail by high resolution solid state(HRSS) 13C NMR using cross polarization,magic angle spinning(CP/MAS)and total suppression of sidebands(TOSS) techniques. Some new information about the splitting peaks of 13C-for-COO- group are given. On the basis of them,the coordination of imidazole group was discussed. The crystal field strength of the Gd(Ⅲ) complex was investigated by EPR spectrometry. The experimental results show that Er3+ complex has some biological activities and could dispose of O2·-.
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