引用本文:
冀亚飞, 宗志敏, 魏贤勇. 3,4,5-三甲氧基苯甲醛的合成[J]. 应用化学,
2001, 18(7): 581-583.
Citation: JI Ya-Fei, ZONG Zhi-Min, WEI Xian-Yong. Synthesis of 3,4,5-Trimethoxybenzaldehyde[J]. Chinese Journal of Applied Chemistry, 2001, 18(7): 581-583.
Citation: JI Ya-Fei, ZONG Zhi-Min, WEI Xian-Yong. Synthesis of 3,4,5-Trimethoxybenzaldehyde[J]. Chinese Journal of Applied Chemistry, 2001, 18(7): 581-583.
3,4,5-三甲氧基苯甲醛的合成
English
Synthesis of 3,4,5-Trimethoxybenzaldehyde
Abstract:
3,4,5-Trimethoxybenzaldehyde was synthesized from p-cresol in an overall yield of 64 5%.p-Cresol was at first brominated and hydrolyzed to give 3,5-dibromo-4-hydroxybenzal-dehyde, which was methoxylated by methanolic sodium methoxide in the presence of cuprous chloride and dimethylformamide(DMF) at 125℃(ca.0.5 MPa) to provide sodium phenolate of 3,5-dimethoxy-4-hydroxybenzaldehyde, from which 3,4,5-trimethoxybenzaldehyde was obtained by methylation directly with dimethyl sulfate in aqueous sodium hydroxide."One-pot" method was used in the synthesis starting from economical, convenient and environmental awareness.
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Key words:
- trimethoxybenzaldehyde
- / p-cresol
- / synthesis
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