引用本文:
王有名, 李正名, 韩玉芬, 贾保军, 王玉林. 3-杂环胺基甲烯基-6-烷基(芳基)-5,6-二氢-2H-吡喃-2,4-二酮的合成及生物活性的研究[J]. 应用化学,
2001, 18(7): 524-527.
Citation: WANG You-Ming, LI Zheng-Ming, HAN Yu-Fen, JIA Bao-Jun, WANG Yu-Lin. Synthesis and Fungicidal Activity of 3-Heterocyclic aminomethylene-5,6-Dihydro-6-alkyl(aryl)-2H-pyran-2,4-diones[J]. Chinese Journal of Applied Chemistry, 2001, 18(7): 524-527.
Citation: WANG You-Ming, LI Zheng-Ming, HAN Yu-Fen, JIA Bao-Jun, WANG Yu-Lin. Synthesis and Fungicidal Activity of 3-Heterocyclic aminomethylene-5,6-Dihydro-6-alkyl(aryl)-2H-pyran-2,4-diones[J]. Chinese Journal of Applied Chemistry, 2001, 18(7): 524-527.
3-杂环胺基甲烯基-6-烷基(芳基)-5,6-二氢-2H-吡喃-2,4-二酮的合成及生物活性的研究
摘要:
采用5,6-二氢-6-烷基(芳基)-2H-吡喃-2,4-二酮,原甲酸三乙酯和杂环胺进行缩合反应,合成了16种3-杂环胺基甲烯基-6-正丙基(苯基)-5,6-二氢-2H-吡喃-2,4-二酮.其结构经1H NMR和元素分析证实.由于两种不同的分子内氢键的形成,化合物由一对异构体组成.生物活性初步测试表明,该类化合物具有一定的杀菌活性.
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关键词:
- 杂环胺基甲烯基正丙基(苯基)二氢吡喃二酮
- / 分子内氢键
- / 异构体
- / 生物活性
English
Synthesis and Fungicidal Activity of 3-Heterocyclic aminomethylene-5,6-Dihydro-6-alkyl(aryl)-2H-pyran-2,4-diones
Abstract:
3-Heterocyclic aminomethylene-5,6-dihydro-6-alkyl(aryl)-2H-pyran-2,4-diones(3) were prepared by the condensation reaction of 6-alkyl(aryl)-5,6-dihydro-2H-pyran-2,4-diones with ethyl orthoformate and heterocyclic amines.A pair of conformational isomers was existed in products 3 due to the intramolecular hydrogen bonding.3 were tested in vitro against H.Oryzae, B.Cinerae and S.Sclerotiorum, showing some fungicidal activity.
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