引用本文:
温辉梁, 周小英, 胡晓波, 章金兵. 2-硝基-4-氯-2'-羟基-3'-特丁基-5'-甲基偶氮苯的固相合成[J]. 应用化学,
2006, 23(5): 579-580.
Citation: WEN Hui-Liang, ZHOU Xiao-Ying, HU Xiao-Bo, ZHANG Jin-Bing. Solid Phase Synthesis of 2-Nitro-4-chloro-2'-hydroxy-3'-t-butyl-5'-methyl-azobenzene[J]. Chinese Journal of Applied Chemistry, 2006, 23(5): 579-580.
Citation: WEN Hui-Liang, ZHOU Xiao-Ying, HU Xiao-Bo, ZHANG Jin-Bing. Solid Phase Synthesis of 2-Nitro-4-chloro-2'-hydroxy-3'-t-butyl-5'-methyl-azobenzene[J]. Chinese Journal of Applied Chemistry, 2006, 23(5): 579-580.
2-硝基-4-氯-2'-羟基-3'-特丁基-5'-甲基偶氮苯的固相合成
摘要:
在室温下,以对氯邻硝基苯胺邻叔丁基对甲基苯酚和亚硝酸钠为原料通过固相重氮偶合反应一步合成了2-硝基-4-氯-2'-羟基-3'-特丁基-5'-甲基偶氮苯。反应时间15 min,产率达93%。以HPLC分析,其纯度>99%,并用IR和UV光谱等对其结构进行了表征和确认。
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关键词:
- 硝基氯羟基特丁基甲基偶氮苯
- / 固相合成
- / 重氮偶合
English
Solid Phase Synthesis of 2-Nitro-4-chloro-2'-hydroxy-3'-t-butyl-5'-methyl-azobenzene
Abstract:
2-Nitro-4-chloro-2'-hydroxy-3'-t-butyl-5'-methyl-azobenzene was synthesized via diazo coupling reaction in solid phase with 4-chlor-2-nitroaniline,2-t-butyl-4-methyl phenol and sodium nitrite at room temperature.The reaction was completed through one-step method within 15 min in a yield of 93% with a higher than 99% purity(by HPLC),and the structure of the compound was comfirmed by IR and UV.
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