引用本文:
鲁俊, 杨海浪, 赵良俊, 肖超渤. 定位选择合成柠檬酸月桂醇单酯[J]. 应用化学,
2006, 23(10): 1176-1178.
Citation: LU Jun, YANG Hai-Lang, ZHAO Liang-Jun, XIAO Chao-Bo. Regioselective Synthesis of Monolauryl Citrate[J]. Chinese Journal of Applied Chemistry, 2006, 23(10): 1176-1178.
Citation: LU Jun, YANG Hai-Lang, ZHAO Liang-Jun, XIAO Chao-Bo. Regioselective Synthesis of Monolauryl Citrate[J]. Chinese Journal of Applied Chemistry, 2006, 23(10): 1176-1178.
定位选择合成柠檬酸月桂醇单酯
English
Regioselective Synthesis of Monolauryl Citrate
Abstract:
Monolauryl citrate was synthesized by regioselective esterification.Reaction of citric acid with paraformaldehyde gave anhydromethylene citric acid(Ⅰ) with a yield of 63%;the reaction of compound(Ⅰ) with acetic anhydride gave the corresponding anhydride(Ⅱ) with a yield of 87%;the esterification of compound(Ⅱ) with lauryl alcohol gave anhydrocitric acid monoester(Ⅲ) with a yield of 76%.Refluxing(Ⅲ) with 1 equivalent of base in aqueous dioxane,the monolauryl citrate was obtained with a yield of 83%.All the compounds were characterized by means of 1H NMR,IR and Elemental Analysis.
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Key words:
- regioselective
- / anhydromethylene citric acid
- / citric acid monoester
- / synthesis
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