引用本文:
蒋建中, 蔡春. 微乳介质中卤代芳烃Ullmann偶联反应[J]. 应用化学,
2006, 23(10): 1140-1144.
Citation: JIANG Jian-Zhong, CAI Chun. Ullmann Coupling Reactions of Aryl Halides in Microemulsion[J]. Chinese Journal of Applied Chemistry, 2006, 23(10): 1140-1144.
Citation: JIANG Jian-Zhong, CAI Chun. Ullmann Coupling Reactions of Aryl Halides in Microemulsion[J]. Chinese Journal of Applied Chemistry, 2006, 23(10): 1140-1144.
微乳介质中卤代芳烃Ullmann偶联反应
摘要:
研究了溴苯在O/W Triton X10微乳(ME)体系和两相体系中Pd/C催化卤代烷烃Ullmann偶联反应。结果表明,微乳体系中联苯收率高于两相体系;比较了在离子、非离子表面活性剂构成的不同微乳体系中的反应活性;研究了卤代芳烃在TX10 ME(O/W)中的甲酸钠、碱类型、Pd/C用量、温度等对反应的影响。研究结果表明,当甲酸钠摩尔分数为10%,缚酸剂为碳酸钾和氢氧化钠的复配物;当Pd/C摩尔分数为2%,反应温度80℃及添加助表面活性剂四丁基氯化铵(TBAC)时,氯苯转化率为100%,联苯的选择性为98%。添加TBAC等阳离子表面活性剂能促进反应。因此微乳可作为Ullmann偶联反应的有效反应体系。
English
Ullmann Coupling Reactions of Aryl Halides in Microemulsion
Abstract:
Ligand free Ullmann coupling reactions of aryl halides catalyzed by Pd/C were studied in O/W Triton X10 microemulsion(ME) in comparison with biphase systems.The yield of biphenyl in a Triton X10 ME system was found higher than that in the biphase system.The reactivities in different ME were also studied.The amount of sodium formate,base type,the amount of Pd/C,temperature on the conversion and selectivity of the coupling reaction were investigated.High conversion(up to 100%) and selectivity(up to 98%) of the reaction could be achieved when 10%(molar fraction) sodium fomate,2%(molar fraction) Pd/C,potassium carbonate and sodium hydroxide as base,80℃ reaction temperature and tetrabutylammo-nium chloride were used.Therefore,the microemulsion is an alternative reaction medium for Ullmann reaction.
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Key words:
- coupling reaction
- / microemulsion
- / aryl halide
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