引用本文:
周婕, 杨亦文, 吴平东. 苯异氰酸酯基环糊精对氟西汀对映体的吸附性能[J]. 应用化学,
2007, 24(5): 575-579.
Citation: ZHOU Jie, YANG Yi-Wen, WU Ping-Dong. Adsorption Properties of Phenylcarbamolyted β-Cyclodextrin for Fluoxetine Enantiomers[J]. Chinese Journal of Applied Chemistry, 2007, 24(5): 575-579.
Citation: ZHOU Jie, YANG Yi-Wen, WU Ping-Dong. Adsorption Properties of Phenylcarbamolyted β-Cyclodextrin for Fluoxetine Enantiomers[J]. Chinese Journal of Applied Chemistry, 2007, 24(5): 575-579.
苯异氰酸酯基环糊精对氟西汀对映体的吸附性能
摘要:
采用手性柱Cyclobond Ⅰ2000 DM的HPLC分析法,研究了自制的手性识别剂——苯异氰酸酯基-β-环糊精对抗抑郁药氟西汀对映体的吸附选择性,测定了3种温度下的静态吸附等温线。实验发现,在甲醇-缓冲液体系下,S-氟西汀在苯异氰酸酯基环糊精上的吸附量总是大于R-氟西汀,2种对映体的等温吸附均符合Langmuir等温吸附方程,并且为优惠吸附;在乙腈-缓冲液体系下,S-氟西汀在苯异氰酸酯基环糊精上的吸附量亦总是大于R-氟西汀,而2种对映体的等温吸附用Freundlich等温吸附方程能更好地描述。结果表明,手性识别剂苯异氰酸酯基-β-环糊精对外消旋物——盐酸氟西汀的2种对映体具有选择性吸附作用,可用于外消旋氟西汀对映体的拆分。
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关键词:
- 氟西汀
- / 苯异氰酸酯基-β-环糊精
- / 对映体
- / 吸附
- / 选择性
English
Adsorption Properties of Phenylcarbamolyted β-Cyclodextrin for Fluoxetine Enantiomers
Abstract:
The adsorption selectivity of fluoxetine enantiomers on phenylcarbamolyted β-cyclodextrin was investigated by HPLC on a Cyclobond Ⅰ 2000 DM column.The isothermal adsorption curves were measured at three temperatures.It was found that in a methanol-buffer solution system the adsorptive capacity of Sfluoxetine on phenylcarbamolyted β-cyclodextrin is always greater than that of R-fluoxetine,and the isothermal adsorption of both enantiomers matches the Langumir isotherm adsorption equation and is advantageous adsorption.It was also found that in an acetonitrile-buffer solution system the adsorptive capacity of S-fluoxetine on phenylcarbamolyted β-cyclodextrin is also greater than that of R-fluoxetine,but it matches the Freundlich isotherm equation.Experimental results show that fluoxetine enantiomers can be resolved probably by HPLC on a phenylcarbamolyted β-cyclodextrin column.
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Key words:
- fluoxetine
- / phenylcarbamolyted β-cyclodextrin
- / enantiomer
- / adsorption
- / selectiviy
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