引用本文:
王陆瑶, 田敏, 胡文祥, 史真. 微波催化新型杂环基苯并咪唑杀菌剂的合成、表征及活性测定[J]. 应用化学,
2007, 24(5): 507-511.
Citation: WANG Lu-Yao, TIAN Min, HU Wen-Xiang, SHI Zhen. Ferrocenesulfonyl Benzimidazole Derivatives Synthesized under Microwave Irradiation and Their Crystal Structure and Antimicrobial Activity[J]. Chinese Journal of Applied Chemistry, 2007, 24(5): 507-511.
Citation: WANG Lu-Yao, TIAN Min, HU Wen-Xiang, SHI Zhen. Ferrocenesulfonyl Benzimidazole Derivatives Synthesized under Microwave Irradiation and Their Crystal Structure and Antimicrobial Activity[J]. Chinese Journal of Applied Chemistry, 2007, 24(5): 507-511.
微波催化新型杂环基苯并咪唑杀菌剂的合成、表征及活性测定
摘要:
以邻苯二胺及相应羧酸为原料,经环化、二茂铁磺酰化,合成了4种未见文献报道的二茂铁磺酰基苯并咪唑衍生物,经元素分析、MS、1H NMR测试技术确证结构。通过X射线衍射,测定了化合物4b的晶体结构,该晶体属单斜晶系,空间群P2(1)/c。晶胞参数:a=0.983 45(6) nm,b=1.702 37(11) nm,c=1.180 96(7) nm,α=90°,β=100.998(4)°,γ=90°,V=1.144 3(2) nm3,Z=4,F(000)=1 744,Mr=443.30,Dc=1.517 g/cm3,R1=0.098 3,wR2=0.110 1。通过琼脂稀释法初步测定了目标化合物4a~4d的杀菌活性,并与商品化的苯并咪唑杀菌剂麦穗宁进行对照试验。结果表明,化合物4a~4d具有良好的杀菌活性,其中化合物4d杀菌活性最高,对5个被测菌种的EC50在17.12~37.11 mg/L。
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关键词:
- 二茂铁磺酰基苯并咪唑
- / 合成
- / 晶体结构
- / 杀菌活性
English
Ferrocenesulfonyl Benzimidazole Derivatives Synthesized under Microwave Irradiation and Their Crystal Structure and Antimicrobial Activity
Abstract:
Four Benzimidazole ferrocenesulfonyl derivatives were prepared by the reaction of ferrocenesulfonylchloride with the corresponding benzimidazoles under microwave irradiation.The compounds were characte-rized by means of elemental analysis,MS and 1H NMR.Henna prismatic crystals of compound 4b were obtained,and the crystal structure was determined by virtue of X-ray diffraction.The crystal is monoclinic with space group P2(1)/c,and the unit cell parameters are a=0.983 45(6) nm,b=1.702 37(11) nm,c=1.180 96(7) nm,α=90°,β=100.998(4)°,γ=90°,V=1.144 3(2) nm3,Z=4,F(000)=1 744,Mr=443.30,Dc=1.517 g/cm3,R1=0.098 3,wR2=0.110 1.The preliminary bioassay results indicate that compounds 4a~4d have antimicrobial activity to a certain degree.Compound 4d shows excellent activities against 5 kinds of tested fungus at EC50 17.12~37.11 mg/L.
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Key words:
- ferrocenesulfonyl benzimidazole
- / synthesis
- / crystal structure
- / antimicrobial activity
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