注册 English

钌(Ⅱ)配合物[Ru(dpq)2L]4+的合成、晶体结构及与G-四链体DNA的相互作用

孙静 ,  宋兴栋 ,  陈文秀 ,  赵轩昊 ,  陈嘉曦 ,  贾振斌 ,  郝洪庆

downloadPDF
引用本文: 孙静, 宋兴栋, 陈文秀, 赵轩昊, 陈嘉曦, 贾振斌, 郝洪庆. 钌(Ⅱ)配合物[Ru(dpq)2L]4+的合成、晶体结构及与G-四链体DNA的相互作用[J]. 无机化学学报, 2015, (5): 865-872. doi: 10.11862/CJIC.2015.142 shu
Citation:  SUN Jing, SONG Xing-Dong, CHEN Wen-Xiu, ZHAO Xuan-Hao, CHEN Jia-Xi, JIA Zhen-Bin, HAO Hong-Qing. Synthesis, Crystal Structure and Interactions with G-Quadruplex Structures of [Ru(dpq)2L]4+[J]. Chinese Journal of Inorganic Chemistry, 2015, (5): 865-872. doi: 10.11862/CJIC.2015.142 shu

钌(Ⅱ)配合物[Ru(dpq)2L]4+的合成、晶体结构及与G-四链体DNA的相互作用

  • 1.

    1 广东医学院药学院, 东莞 523808;

  • 2.

    2 嘉应学院化学与环境学院, 梅州 514015

    • 通讯作者: 孙静 sunjing03@foxmail.com; 郝洪庆 hqhao@126.com; 孙静 sunjing03@foxmail.com; 郝洪庆 hqhao@126.com
  • 基金项目:

    国家自然科学基金(No.21101034) (No.21101034)

    广东省优秀青年教师培养计划项目(No.Yq2013086,Yq2013151) (No.Yq2013086,Yq2013151)

    东莞市科技计划项目(No.2011108102046) (No.2011108102046)

    广东省大学生创新课题(No.1057112037)项目,2014年广东省本科高校教学质量与教学改革工程立项建设项目资助。 (No.1057112037)

摘要: 以cis-[Ru(dpq)2Cl2]·2H2O(dpq=二吡啶[3,2-d:2',3'-f]二氮萘)为原料与5,5'-二(1-(三乙胺)甲基)-2,2'-联吡啶阳离子(L)合成钌(Ⅱ)配合物[Ru(dpq)2L](PF6)4,并研究了该配合物与G-四链体DNA的作用:FRET实验表明,配合物对人端粒DNAh-telo具有选择性,其作用能力要强于同癌基因启动子区域的四链DNA,如c-myc和bcl2;CD光谱表明,在Na+和K+都不存在的情况下,配合物能诱导h-telo形成平行结构;此外,紫外和发射光谱都显示,配合物在K+溶液中与h-telo的作用力要大于在Na+溶液中的。

English

  • 

    1. [1] Huppert J L, Balasubramanian S. Nucleic Acids Res., 2005, 33:2908-2916[1] Huppert J L, Balasubramanian S. Nucleic Acids Res., 2005, 33:2908-2916

    2. [2] Huppert J L. Chem. Soc. Rev., 2008,37:1375-1384[2] Huppert J L. Chem. Soc. Rev., 2008,37:1375-1384

    3. [3] Murat P, Singh Y, Defrancq E. Chem. Soc. Rev., 2011,40: 5293-5307[3] Murat P, Singh Y, Defrancq E. Chem. Soc. Rev., 2011,40: 5293-5307

    4. [4] Huppert J L, Balasubramanian S. Nucleic Acids Res., 2007, 35:406-413[4] Huppert J L, Balasubramanian S. Nucleic Acids Res., 2007, 35:406-413

    5. [5] Todd A K, Johnston M, Neidle S. Nucleic Acids Res., 2005, 33:2901-2907[5] Todd A K, Johnston M, Neidle S. Nucleic Acids Res., 2005, 33:2901-2907

    6. [6] Reed J E, White A J P, Neidleb S, et al. Dalton Trans., 2009: 2558-2568[6] Reed J E, White A J P, Neidleb S, et al. Dalton Trans., 2009: 2558-2568

    7. [7] Kim N W, Piatyszek M A, Prowse K R, et al. Science, 1994, 266:2011-2015[7] Kim N W, Piatyszek M A, Prowse K R, et al. Science, 1994, 266:2011-2015

    8. [8] Shay J W, Bacchetti S. Eur. J. Cancer, 1997,33:787-791[8] Shay J W, Bacchetti S. Eur. J. Cancer, 1997,33:787-791

    9. [9] Kelland L R. Anticancer Drugs, 2000,11:503-513[9] Kelland L R. Anticancer Drugs, 2000,11:503-513

    10. [10] Suntharalingam K, Gupta D, Miguel P J S, et al. Chem. Eur. J., 2010,16:3613-3616[10] Suntharalingam K, Gupta D, Miguel P J S, et al. Chem. Eur. J., 2010,16:3613-3616

    11. [11] Finkel T, Serrano M, Blasco M A. Nature, 2007,448:767-774[11] Finkel T, Serrano M, Blasco M A. Nature, 2007,448:767-774

    12. [12] Bertrand H, Monchaud D, Cian A D, et al. Org. Biomol. Chem., 2007,5:2555-2559[12] Bertrand H, Monchaud D, Cian A D, et al. Org. Biomol. Chem., 2007,5:2555-2559

    13. [13] SUN Jing(孙静), CHEN Jia-Xi(陈嘉曦), LIN Hai-Ling(林海 玲), et al. Chinese J. Inorg. Chem.(无机化学学报), 2012, 28:45-49[13] SUN Jing(孙静), CHEN Jia-Xi(陈嘉曦), LIN Hai-Ling(林海 玲), et al. Chinese J. Inorg. Chem.(无机化学学报), 2012, 28:45-49

    14. [14] Jain A K, Paul A, Maji B, et al. J. Med. Chem., 2012,55: 2981-2993[14] Jain A K, Paul A, Maji B, et al. J. Med. Chem., 2012,55: 2981-2993

    15. [15] Chen X, Wu J H, Lai Y W, et al. Dalton Trans., 2013:4386-4397[15] Chen X, Wu J H, Lai Y W, et al. Dalton Trans., 2013:4386-4397

    16. [16] Shi S, Huang H L, Gao X, et al. J. Inorg. Biochem., 2013, 121:19-27[16] Shi S, Huang H L, Gao X, et al. J. Inorg. Biochem., 2013, 121:19-27

    17. [17] An Y, Lin Y Y, Wang H, et al. Dalton Trans., 2006:2066-2071[17] An Y, Lin Y Y, Wang H, et al. Dalton Trans., 2006:2066-2071

    18. [18] Paw W, Eisenberg R. Inorg. Chem., 1997,36:2287-2293[18] Paw W, Eisenberg R. Inorg. Chem., 1997,36:2287-2293

    19. [19] Collins J G, Sleeman A D, Aldrich-Wright J R, et al. Inorg. Chem., 1998,37:3133-3141[19] Collins J G, Sleeman A D, Aldrich-Wright J R, et al. Inorg. Chem., 1998,37:3133-3141

    20. [20] Deshpande M S, Kumbhar A A, Kumbhar A S, et al. Bioco-njugate Chem., 2009,20:447-459[20] Deshpande M S, Kumbhar A A, Kumbhar A S, et al. Bioco-njugate Chem., 2009,20:447-459

    21. [21] Sheldrick G M. SADABS, University of Göttingen, Germany, 1996.[21] Sheldrick G M. SADABS, University of Göttingen, Germany, 1996.

    22. [22] Sheldrick G M. SHELXS-97 and SHELXL-97, University of Göttingen, Germany, 1996.[22] Sheldrick G M. SHELXS-97 and SHELXL-97, University of Göttingen, Germany, 1996.

    23. [23] Haq I, Lincoln P, Suh D, et al. J. Am. Chem. Soc., 1995, 117:4788-4796[23] Haq I, Lincoln P, Suh D, et al. J. Am. Chem. Soc., 1995, 117:4788-4796

    24. [24] Haq I, Trent J O, Chowdhry B Z, et al. J. Am. Chem. Soc., 1999,121:1768-1779[24] Haq I, Trent J O, Chowdhry B Z, et al. J. Am. Chem. Soc., 1999,121:1768-1779

    25. [25] Santra B K, Menon M, Pal C K, et al. Dalton Trans., 1997: 1387-1393[25] Santra B K, Menon M, Pal C K, et al. Dalton Trans., 1997: 1387-1393

    26. [26] Sun J, Wu S, An Y, et al. Polyhedron, 2008,27:2845-2850[26] Sun J, Wu S, An Y, et al. Polyhedron, 2008,27:2845-2850

    27. [27] Rillema D P, Jones D S, Woods C, et al. Inorg. Chem., 1992,31:2935-2938[27] Rillema D P, Jones D S, Woods C, et al. Inorg. Chem., 1992,31:2935-2938

    28. [28] Khatua S, Samanta D, Bats J W, et al. Inorg. Chem., 2012, 51:7075-7086[28] Khatua S, Samanta D, Bats J W, et al. Inorg. Chem., 2012, 51:7075-7086

    29. [29] Mergny J L, Maurizot J C. ChemBioChem, 2001,2:124-132[29] Mergny J L, Maurizot J C. ChemBioChem, 2001,2:124-132

    30. [30] Rezler E M, Seenisamy J, Bashyam S, et al. J. Am. Chem. Soc., 2005,127:9439-9447[30] Rezler E M, Seenisamy J, Bashyam S, et al. J. Am. Chem. Soc., 2005,127:9439-9447

    31. [31] Ambrus A, Chen D, Dai J X, et al. Nucleic Acids Res., 2006,34:2723-2735[31] Ambrus A, Chen D, Dai J X, et al. Nucleic Acids Res., 2006,34:2723-2735

    32. [32] Xu Y, Noguchi Y, Sugiyama H. Bioorg. Med. Chem., 2006, 14:5584-5591[32] Xu Y, Noguchi Y, Sugiyama H. Bioorg. Med. Chem., 2006, 14:5584-5591

    33. [33] Antonacci C, Chaires J B, Sheardy R D. Biochemistry, 2007,46:4654-4660[33] Antonacci C, Chaires J B, Sheardy R D. Biochemistry, 2007,46:4654-4660

    34. [34] Dai J X, Punchihewa C, Ambrus A, et al. Nucleic Acids Res., 2007,35:2440-2450[34] Dai J X, Punchihewa C, Ambrus A, et al. Nucleic Acids Res., 2007,35:2440-2450

    35. [35] Li W, Wu P, Ohmichi T, et al. FEBS Lett., 2002,526:77-81[35] Li W, Wu P, Ohmichi T, et al. FEBS Lett., 2002,526:77-81

    36. [36] Zheng X H, Zhong Y F, Tan C P, et al. Dalton Trans., 2012: 11807-11812[36] Zheng X H, Zhong Y F, Tan C P, et al. Dalton Trans., 2012: 11807-11812

    37. [37] Chen L M, Liu J, Chen J C, et al. J. Inorg. Biochem., 2008, 102:330-341[37] Chen L M, Liu J, Chen J C, et al. J. Inorg. Biochem., 2008, 102:330-341

    38. [38] Carter M T, Rodriguez M, Bard A J. J. Am. Chem. Soc., 1989,111:8901-8911[38] Carter M T, Rodriguez M, Bard A J. J. Am. Chem. Soc., 1989,111:8901-8911

    39. [39] Maheswari P U, Palaniandavar M. J. Inorg. Biochem., 2004, 98:219-230[39] Maheswari P U, Palaniandavar M. J. Inorg. Biochem., 2004, 98:219-230

    40. [40] Shi S, Geng X T, Zhao J, et al. Biochimie, 2010,92:370-377[40] Shi S, Geng X T, Zhao J, et al. Biochimie, 2010,92:370-377

    41. [41] Rajput C, Rutkaite R, Swanson L, et al. Chem. Eur. J., 2006,12:4611-4619[41] Rajput C, Rutkaite R, Swanson L, et al. Chem. Eur. J., 2006,12:4611-4619

  • 加载中
WeChat 扫一扫看文章
计量
  • PDF下载量:  0
  • 文章访问数:  1162
  • HTML全文浏览量:  114
文章相关
  • 收稿日期:  2014-11-28
  • 网络出版日期:  2015-03-22
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

/

返回文章

All Rights Reserved by the Chinese Chemical Society   中国化学会 版权所有 京ICP备05002797号

本系统由北京仁和汇智信息技术有限公司开发    技术支持: info@rhhz.net