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有机锡4-(4-吡啶基甲基硫代)苯甲酸酯的合成、结构与生物活性研究

罗华锋 ,  甘贤雪

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引用本文: 罗华锋, 甘贤雪. 有机锡4-(4-吡啶基甲基硫代)苯甲酸酯的合成、结构与生物活性研究[J]. 无机化学学报, 2014, 30(4): 930-936. doi: 10.11862/CJIC.2014.145 shu
Citation:  LUO Hua-Feng, GAN Xian-Xue. Synthesis, Structure and Biological Activity of Triorganotin 4-(4-Pyridylmethylthio)benzoates[J]. Chinese Journal of Inorganic Chemistry, 2014, 30(4): 930-936. doi: 10.11862/CJIC.2014.145 shu

有机锡4-(4-吡啶基甲基硫代)苯甲酸酯的合成、结构与生物活性研究

    通讯作者: 甘贤雪 ganxianxue@sina.com
  • 基金项目:

    四川省教育厅(No.13ZA0204)资助项目。 (No.13ZA0204)

摘要: 通过4-(4-吡啶基甲基硫代)苯甲酸与三苯基氧化锡以及三环己基氢氧化锡反应,合成了三苯基锡4-(4-吡啶基甲基硫代)苯甲酸酯(1)及三环己基锡4-(4-吡啶基甲基硫代)苯甲酸酯(2)。它们的结构通过红外,核磁以及X-射线单晶衍射分析得到确证。化合物1表现为一维链状结构,而化合物2通过分子间的O-H…O和O-H…N氢键形成二维网状结构。生物活性测试表明,这2个化合物具有较高的抗肿瘤活性。

English

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  • 收稿日期:  2013-09-18
  • 网络出版日期:  2013-11-25
通讯作者: 陈斌, bchen63@163.com
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