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Antiviral enantiomers of a bisindole alkaloid with a new carbon skeleton from the roots of Isatis indigotica

Yu-Feng Liu ,  Ming-Hua Chen ,  Xiao-Liang Wang ,  Qing-Lan Guo ,  Cheng-Gen Zhu ,  Sheng Lin ,  Cheng-Bo Xu ,  Yue-Ping Jiang ,  Yu-Huan Li ,  Jian-Dong Jiang ,  Yan Li ,  Jian-Gong Shi

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Citation:  Yu-Feng Liu, Ming-Hua Chen, Xiao-Liang Wang, Qing-Lan Guo, Cheng-Gen Zhu, Sheng Lin, Cheng-Bo Xu, Yue-Ping Jiang, Yu-Huan Li, Jian-Dong Jiang, Yan Li, Jian-Gong Shi. Antiviral enantiomers of a bisindole alkaloid with a new carbon skeleton from the roots of Isatis indigotica[J]. Chinese Chemical Letters, 2015, 26(8): 931-936. doi: 10.1016/j.cclet.2015.05.052 shu

Antiviral enantiomers of a bisindole alkaloid with a new carbon skeleton from the roots of Isatis indigotica

    • 通讯作者: Jian-Gong Shi,
  • 基金项目:

    Innovative Research Team in University (PCSIRT, No. IRT1007) (PCSIRT, No. IRT1007)

摘要: A pair of indole alkaloid enantiomers with a novel bisindolylacetamide skeleton, insatindibisindolamides A and B (1a and 1b), was isolated from an aqueous extract of Isatis indigotica roots. The enantiomers were separated by chiral HPLC. Their structures and absolute configurations were elucidated by extensive spectroscopic analysis, including 2D NMR, X-ray crystallography, and electronic CD (ECD) calculation. The proposed biosynthetic pathway and preliminary investigations of the biological activity of compounds 1a and 1b are also discussed.

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  • 发布日期:  2015-06-05
  • 收稿日期:  2015-04-02
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