Phosphine-promoted [3 + 2] cycloaddition between nonsubstituted MBH carbonates and trifluoromethyl ketones

Hong-Yu Duan Juan Ma Zhe-Zhe Yuan Ri-Sheng Yao Wei Tao Fang Xu Hua Xiao Gang Zhao

Citation:  Hong-Yu Duan, Juan Ma, Zhe-Zhe Yuan, Ri-Sheng Yao, Wei Tao, Fang Xu, Hua Xiao, Gang Zhao. Phosphine-promoted [3 + 2] cycloaddition between nonsubstituted MBH carbonates and trifluoromethyl ketones[J]. Chinese Chemical Letters, 2015, 26(6): 646-648. doi: 10.1016/j.cclet.2015.03.019 shu

Phosphine-promoted [3 + 2] cycloaddition between nonsubstituted MBH carbonates and trifluoromethyl ketones

    通讯作者: Ri-Sheng Yao,
    Hua Xiao,
  • 基金项目:

    This work was supported by the National Natural Science Foundation of China (No. 21302034) (No. 21302034)

    the Fundamental Research Funds for the Central Universities (No. 2013HGQC0028). (No. 2013HGQC0028)

摘要: A phosphine-promoted [3 + 2] cycloaddition from readily accessible MBH (Morita-Baylis-Hillman) carbonate and aryl trifluoromethyl ketone is described. The use of methyl vinyl ketone-derived allylic carbonate rather than common acrylate-derived counterpart renders the reaction pathway exclusive for 5-endo process, which enables the expeditious preparation of a range of trifluoromethylated 2, 3-dihydrofuran in a chemospecific manner.

English

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  • 发布日期:  2015-03-27
  • 收稿日期:  2015-01-14
  • 网络出版日期:  2015-03-04
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