New cytotoxic C-3 dehydrated bufadienolides from the venom of Bufo bufo gargarizans
English
New cytotoxic C-3 dehydrated bufadienolides from the venom of Bufo bufo gargarizans
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Key words:
- Toad venom
- / Bufo bufo gargarizans
- / 3-Dehydrated bufadienolide
- / Cytotoxicity
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[6] D.M. Zhang, J.S. Liu, L.J. Deng, et al., Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway, Carcinogenesis 34 (2013) 1331-1342.[6] D.M. Zhang, J.S. Liu, L.J. Deng, et al., Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway, Carcinogenesis 34 (2013) 1331-1342.
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[8] F.H. Qi, A.Y. Li, L. Zhao, et al., Apoptosis-inducing effect of cinobufacini on human hepatoma cell line HepG2 and its mechanism of action, Acta Pharm. Sin. 45 (2010) 318-323.[8] F.H. Qi, A.Y. Li, L. Zhao, et al., Apoptosis-inducing effect of cinobufacini on human hepatoma cell line HepG2 and its mechanism of action, Acta Pharm. Sin. 45 (2010) 318-323.
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[9] H.Y. Tian, L. Wang, X.Q. Zhang, et al., Bufogargarizins A and B: two novel 19-norbufadienolides with unprecedented skeletons from the venom of Bufo bufo gargarizans, Chem. Eur. J. 16 (2010) 10989-10993.[9] H.Y. Tian, L. Wang, X.Q. Zhang, et al., Bufogargarizins A and B: two novel 19-norbufadienolides with unprecedented skeletons from the venom of Bufo bufo gargarizans, Chem. Eur. J. 16 (2010) 10989-10993.
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[14] Y. Kamano, A. Kotake, R. Takano, et al., Conformational preference of two toad poison bufadienolides, bufarenogin and ψ-bufarenogin, Heterocycles 49 (1998) 275-279.[14] Y. Kamano, A. Kotake, R. Takano, et al., Conformational preference of two toad poison bufadienolides, bufarenogin and ψ-bufarenogin, Heterocycles 49 (1998) 275-279.
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[15] H.Y. Tian, X.F. Yuan, L. Jin, et al., A bufadienolide derived androgen receptor antagonist with inhibitory activities against prostate cancer cells, Chem. Biol. Interact. 207 (2014) 16-22.[15] H.Y. Tian, X.F. Yuan, L. Jin, et al., A bufadienolide derived androgen receptor antagonist with inhibitory activities against prostate cancer cells, Chem. Biol. Interact. 207 (2014) 16-22.
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