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An effi cient one-pot three-component synthesis and antimicrobial evaluation of tetra substituted thiophene derivatives

Pravinkumar N. Sable ,  Swastika Ganguly ,  Pravin D. Chaudhari

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Citation:  Pravinkumar N. Sable, Swastika Ganguly, Pravin D. Chaudhari. An effi cient one-pot three-component synthesis and antimicrobial evaluation of tetra substituted thiophene derivatives[J]. Chinese Chemical Letters, 2014, 25(7): 1099-1103. doi: 10.1016/j.cclet.2014.03.044 shu

An effi cient one-pot three-component synthesis and antimicrobial evaluation of tetra substituted thiophene derivatives

    • 通讯作者: Pravinkumar N. Sable,
摘要: A convenient one-pot three-component method for the preparation of tetra-substituted thiophene derivatives has been developed. Reaction of acetyl acetone 1, phenyl isothiocynate 2 and 2-chloromethyl derivatives 3a-3c in the presence of potassium carbonate afforded the target compounds, namely ethyl 2-(4-acetyl-3-methyl-5-(phenylamino)thiophen-2-yl)-2-oxoacetate derivatives 4a-4e, ethyl 3-(4-acetyl-3-methyl-5-(phenylamino)thiophen-2-yl)-3-oxopropanoate derivatives 4f-4i, di((4-acetyl-3-methyl-5-phenylamino)thiophen-2-yl)ketone derivatives 4j-4n in reasonable overall yields. The synthesized compounds were screened for antimicrobial activity. The detailed synthesis, spectroscopic data and antimicrobial activities of synthesized compounds were reported.

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  • 收稿日期:  2013-09-11
  • 网络出版日期:  2014-03-04
通讯作者: 陈斌, bchen63@163.com
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