Synthesis of N-arylquinolone derivatives bearing 2-thiophenoxyquinolines and their antimicrobial evaluation

Mehul B. Kanani Manish P. Patel

Citation:  Mehul B. Kanani, Manish P. Patel. Synthesis of N-arylquinolone derivatives bearing 2-thiophenoxyquinolines and their antimicrobial evaluation[J]. Chinese Chemical Letters, 2014, 25(7): 1073-1076. doi: 10.1016/j.cclet.2014.04.002 shu

Synthesis of N-arylquinolone derivatives bearing 2-thiophenoxyquinolines and their antimicrobial evaluation

    通讯作者: Manish P. Patel,
摘要: A new series of 2-thiophenoxyquinolines based trifluoromethyl substituted N-aryl quinolone derivatives 8a-f and 9a-f have been synthesized via a one-pot multicomponent reaction. In vitro antimicrobial activity of the synthesized compounds was investigated against a representative panel of pathogenic strains. Compounds 8c, 9c and 9e exhibited comparable antimicrobial activity to first line drugs.

English

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  • 收稿日期:  2013-12-03
  • 网络出版日期:  2014-03-25
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