Synthesis of novel, azasugar-modifi ed anthraquinone derivatives and their cytotoxicity

注册 English

Synthesis of novel, azasugar-modifi ed anthraquinone derivatives and their cytotoxicity

Ping-Zhu Zhang , Hai-Long Yang , Cui-Cui Li , Zhi-Chao Xia , Xiao-Man Wang , Hua Wei , Rui-Xue Rong , Zhi-Ran Cao , Ke-Rang Wang , Hua Chen , Xiao-Liu Li

Citation: Ping-Zhu Zhang, Hai-Long Yang, Cui-Cui Li, Zhi-Chao Xia, Xiao-Man Wang, Hua Wei, Rui-Xue Rong, Zhi-Ran Cao, Ke-Rang Wang, Hua Chen, Xiao-Liu Li. Synthesis of novel, azasugar-modifi ed anthraquinone derivatives and their cytotoxicity[J]. Chinese Chemical Letters, 2014, 25(7): 1057-1059. doi: 10.1016/j.cclet.2014.05.029 shu

shu

Synthesis of novel, azasugar-modifi ed anthraquinone derivatives and their cytotoxicity

通讯作者: Xiao-Liu Li,

基金项目:

the Hebei Key Basic Research (No. 12966417D) (No. 12966417D)

the Hebei Natural Science Foundation (No. B2012201041) (No. B2012201041)

the Foundation of Hebei Education Department (No. YQ2013006). (No. YQ2013006)

摘要: A series of novel, azasugar-modified 2-monosubstituted, 2,6-and 2,7-bissubstituted anthraquinone derivatives have been synthesized by the nucleophilic substitution of N-alkylamino azasugar with mono-, bis(2-chloroacetamido)anthraquinones. Their cytotoxic activities against HeLa and MCF-7 cells were preliminarily evaluated and compound 9a with mono-azasugar pendant at 2-position showed similar activity to the control drug (Cisplatin).

关键词:

English

Synthesis of novel, azasugar-modifi ed anthraquinone derivatives and their cytotoxicity

1.
a Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China;
2.
b Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding 071002, China;
3.
c Department of Immunology, School of Basic Medical Science, Hebei University, Baoding 071002, China

Corresponding author: Xiao-Liu Li,

Received Date: 31 March 2014
Fund Project:

Abstract: A series of novel, azasugar-modified 2-monosubstituted, 2,6-and 2,7-bissubstituted anthraquinone derivatives have been synthesized by the nucleophilic substitution of N-alkylamino azasugar with mono-, bis(2-chloroacetamido)anthraquinones. Their cytotoxic activities against HeLa and MCF-7 cells were preliminarily evaluated and compound 9a with mono-azasugar pendant at 2-position showed similar activity to the control drug (Cisplatin).

Key words:

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