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Inhibitory effect of eleven herbal extracts on advanced glycation end-products formation and aldose reductase activity

Guang-Yue Hou ,  Lu Wang ,  Shu Liu ,  Feng-Rui Song ,  Zhi-Qiang Liu

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Citation:  Guang-Yue Hou, Lu Wang, Shu Liu, Feng-Rui Song, Zhi-Qiang Liu. Inhibitory effect of eleven herbal extracts on advanced glycation end-products formation and aldose reductase activity[J]. Chinese Chemical Letters, 2014, 25(7): 1039-1043. doi: 10.1016/j.cclet.2014.04.029 shu

Inhibitory effect of eleven herbal extracts on advanced glycation end-products formation and aldose reductase activity

    • 通讯作者: Feng-Rui Song,
  • 基金项目:

    This research was financially supported by the National Natural Science Foundation of China (No. 81373952)  (No. 81373952)

    the Innovation Method Fund of China (No. 2012IM030600). (No. 2012IM030600)

摘要: The formation of advanced glycation end-products (AGEs) and aldose reductase (AR) activity have been implicated in the development of diabetic complications. Our study sought to characterize the capacities of eleven herbal extracts against the formation of AGEs and the AR activity. An ultrahigh performance liquid chromatography and tandem mass spectrometry (UPLC-MS/MS) method was used for the detection of AR activity and the screening of AR inhibitors in this research. The amount of sorbitol from each analyte was directly detected using the multiple reaction monitoring mode and the sorbitol level could be reduced via the addition of an inhibitor. Moreover, the BSA/glucose (fructose) system was applied to investigate their inhibitory activities of AGEs formation in glycation model reactions. Compared with other screened herbs used in our study, Flos Sophorae Immaturus and Radix Scutellariae seemed to bemore effective on inhibiting the formation of AGEs and AR activity. The inhibiting capacities of herbal extracts against AR activity and AGEs formation may be correlated with the bioactive components of the herbal extracts. The differences were correlated with the amount of polyphenol and flavonoid components. In the study, we have investigated the potential anti-hyperglycemic bioactivity of eleven herbal extracts in vivo, which could provide a reference for further in vivo research in the prevention and treatment of diabetic complications.

English

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    1. [1] D.J. Porte, M.W. Schwartz, Diabetes complications: why is glucose potentially toxic? Science 272 (1996) 699-700.[1] D.J. Porte, M.W. Schwartz, Diabetes complications: why is glucose potentially toxic? Science 272 (1996) 699-700.

    2. [2] I.M. Stratton, A.I. Adler, H.A. Neil, et al., Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study, Br. Med. J. 321 (2000) 405-412.[2] I.M. Stratton, A.I. Adler, H.A. Neil, et al., Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study, Br. Med. J. 321 (2000) 405-412.

    3. [3] R. Ramasamy, I.J. Goldberg, Aldose reductase and cardiovascular diseases, creating human-like diabetic complications in an experimental model, Circ. Res. 106 (2010) 1449-1458.[3] R. Ramasamy, I.J. Goldberg, Aldose reductase and cardiovascular diseases, creating human-like diabetic complications in an experimental model, Circ. Res. 106 (2010) 1449-1458.

    4. [4] M. Brownlee, Biochemistry and molecular cell biology of diabetic complications, Nature 414 (2001) 813-820.[4] M. Brownlee, Biochemistry and molecular cell biology of diabetic complications, Nature 414 (2001) 813-820.

    5. [5] J.T. Xie, A. Wang, S. Mehendale, et al., Anti-diabetic effects of Gymnema yunnanense extract, Pharmacol. Res. 47 (2003) 323-329.[5] J.T. Xie, A. Wang, S. Mehendale, et al., Anti-diabetic effects of Gymnema yunnanense extract, Pharmacol. Res. 47 (2003) 323-329.

    6. [6] R.A. DeFronzo, Pharmacologic therapy for type 2 diabetes mellitus, Ann. Intern. Med. 131 (1999) 281-303.[6] R.A. DeFronzo, Pharmacologic therapy for type 2 diabetes mellitus, Ann. Intern. Med. 131 (1999) 281-303.

    7. [7] K. Tsuji-Naito, H. Saeki, M. Hamano, Inhibitory effects of Chrysanthemum species extracts on formation of advanced glycation end products, Food Chem. 116 (2009) 854-859.[7] K. Tsuji-Naito, H. Saeki, M. Hamano, Inhibitory effects of Chrysanthemum species extracts on formation of advanced glycation end products, Food Chem. 116 (2009) 854-859.

    8. [8] O. El-Kabbani, F. Ruiz, C. Darmanin, R.P. Chung, Aldose reductase structures: implications for mechanism and inhibition, Cell. Mol. Life Sci. 61 (2004) 750-762.[8] O. El-Kabbani, F. Ruiz, C. Darmanin, R.P. Chung, Aldose reductase structures: implications for mechanism and inhibition, Cell. Mol. Life Sci. 61 (2004) 750-762.

    9. [9] D.K. Wilson, K.M. Bohren, K.H. Gabbay, F.A. Quiocho, An unlikely sugar substrate site in the 1.65Åstructure of the human aldose reductase holoenzyme implicated in diabetic complications, Science 257 (1992) 81-84.[9] D.K. Wilson, K.M. Bohren, K.H. Gabbay, F.A. Quiocho, An unlikely sugar substrate site in the 1.65Åstructure of the human aldose reductase holoenzyme implicated in diabetic complications, Science 257 (1992) 81-84.

    10. [10] H. Pareek, S. Sharma, B.S. Khajja, K. Jain, G.C. Jain, Evaluation of hypoglycemic and anti-hyperglycemic potential of Tridax procumbens (Linn.), BMC Complem. Alter. Med. 9 (2009) 48-54.[10] H. Pareek, S. Sharma, B.S. Khajja, K. Jain, G.C. Jain, Evaluation of hypoglycemic and anti-hyperglycemic potential of Tridax procumbens (Linn.), BMC Complem. Alter. Med. 9 (2009) 48-54.

    11. [11] D. Normile, The new face of traditional Chinese medicine, Science 299 (2003) 188-190.[11] D. Normile, The new face of traditional Chinese medicine, Science 299 (2003) 188-190.

    12. [12] J. Yin, H. Zhang, J. Ye, Traditional Chinese medicine in treatment of metabolic syndrome, Endocr. Metab. Immune. Disord. Drug Targets. 8 (2008) 99-111.[12] J. Yin, H. Zhang, J. Ye, Traditional Chinese medicine in treatment of metabolic syndrome, Endocr. Metab. Immune. Disord. Drug Targets. 8 (2008) 99-111.

    13. [13] L. Liu, J.A. Duan, Y. Tang, et al., Taoren-Honghua herb pair and its main components promoting blood circulation through influencing on hemorheology, plasma coagulation and platelet aggregation, J. Ethnopharmacol. 139 (2012) 381-387.[13] L. Liu, J.A. Duan, Y. Tang, et al., Taoren-Honghua herb pair and its main components promoting blood circulation through influencing on hemorheology, plasma coagulation and platelet aggregation, J. Ethnopharmacol. 139 (2012) 381-387.

    14. [14] S. Hayman, J.H. Kinoshita, Isolation and properties of lens aldose reductase, J. Biol. Chem. 240 (1965) 877-882.[14] S. Hayman, J.H. Kinoshita, Isolation and properties of lens aldose reductase, J. Biol. Chem. 240 (1965) 877-882.

    15. [15] C. Nishimura, T. Yamaoka, M. Mizutani, et al., Purification and characterization of the recombinant human aldose reductase expressed in baculovirus system, Biochim. Biophys. Acta 1078 (1991) 171-178.[15] C. Nishimura, T. Yamaoka, M. Mizutani, et al., Purification and characterization of the recombinant human aldose reductase expressed in baculovirus system, Biochim. Biophys. Acta 1078 (1991) 171-178.

    16. [16] J.A. Vinson, T.B. Howard III, Inhibition of protein glycation and advanced glycation end products by ascorbic acid and other vitamins and nutrients, J. Nutr. Biochem. 7 (1996) 659-663.[16] J.A. Vinson, T.B. Howard III, Inhibition of protein glycation and advanced glycation end products by ascorbic acid and other vitamins and nutrients, J. Nutr. Biochem. 7 (1996) 659-663.

    17. [17] J.Y. Wang, S.G. Zhu, C.F. Xu, Biochemistry, 3rd ed., Higher Education Press, Beijing, 2007.[17] J.Y. Wang, S.G. Zhu, C.F. Xu, Biochemistry, 3rd ed., Higher Education Press, Beijing, 2007.

    18. [18] Y. Kawanishi, S. Noparatanawong, S. Kamohara, M. Nakano, Antioxidants supplementation prevents exercise induced oxidative damage in healthy subjects, J. Am. Diet. Assoc. 103 (2003) 36.[18] Y. Kawanishi, S. Noparatanawong, S. Kamohara, M. Nakano, Antioxidants supplementation prevents exercise induced oxidative damage in healthy subjects, J. Am. Diet. Assoc. 103 (2003) 36.

    19. [19] C.S. Wu, Y. Jin, J.L. Zhang, Y. Ren, Z.X. Jia, Simultaneous determination of seven prohibited substances in cosmetic products by liquid chromatography-tandem mass spectrometry, Chin. Chem. Lett. 24 (2013) 509-511.[19] C.S. Wu, Y. Jin, J.L. Zhang, Y. Ren, Z.X. Jia, Simultaneous determination of seven prohibited substances in cosmetic products by liquid chromatography-tandem mass spectrometry, Chin. Chem. Lett. 24 (2013) 509-511.

    20. [20] S. Liu, J.P. Xing, Z. Zheng, et al., Ultrahigh performance liquid chromatography-triple quadrupole mass spectrometry inhibitors fishing assay: a novel method for simultaneously screening of xanthine oxidase inhibitor and superoxide anion scavenger in a single analysis, Anal. Chim. Acta 715 (2012) 64-70.[20] S. Liu, J.P. Xing, Z. Zheng, et al., Ultrahigh performance liquid chromatography-triple quadrupole mass spectrometry inhibitors fishing assay: a novel method for simultaneously screening of xanthine oxidase inhibitor and superoxide anion scavenger in a single analysis, Anal. Chim. Acta 715 (2012) 64-70.

    21. [21] N. Hotta, Y. Akanuma, R. Kawamori, et al., Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: the 3-year, multicenter, comparative aldose reductase inhibitor-diabetes complications trial, Diabetes Care 29 (2006) 1538-1544.[21] N. Hotta, Y. Akanuma, R. Kawamori, et al., Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: the 3-year, multicenter, comparative aldose reductase inhibitor-diabetes complications trial, Diabetes Care 29 (2006) 1538-1544.

    22. [22] H.A. Jung, M.D. Islam, Y.S. Kwon, et al., Extraction and identification of three major aldose reductase inhibitors from Artemisia montana, Food Chem. Toxicol. 49 (2011) 376-384.[22] H.A. Jung, M.D. Islam, Y.S. Kwon, et al., Extraction and identification of three major aldose reductase inhibitors from Artemisia montana, Food Chem. Toxicol. 49 (2011) 376-384.

    23. [23] K. Kawanishi, H. Ueda, M. Moriyasu, Aldose reductase inhibitors from the nature, Curr. Med. Chem. 10 (2003) 1353-1374.[23] K. Kawanishi, H. Ueda, M. Moriyasu, Aldose reductase inhibitors from the nature, Curr. Med. Chem. 10 (2003) 1353-1374.

    24. [24] J.Á. de la Fuente, S. Manzanaro, Aldose reductase inhibitors from natural sources, Nat. Prod. Rep. 20 (2003) 243-251.[24] J.Á. de la Fuente, S. Manzanaro, Aldose reductase inhibitors from natural sources, Nat. Prod. Rep. 20 (2003) 243-251.

    25. [25] S. Katayama, Y. Haga, H. Saeki, Loss of filament-forming ability of myosin by nonenzymatic glycosylation and its molecular mechanism, FEBS Lett. 575 (2004) 9-13.[25] S. Katayama, Y. Haga, H. Saeki, Loss of filament-forming ability of myosin by nonenzymatic glycosylation and its molecular mechanism, FEBS Lett. 575 (2004) 9-13.

    26. [26] T. Manaharan, L.L. Teng, D. Appleton, et al., Antioxidant and antiglycemic potential of Peltophorum pterocarpum plant parts, Food Chem. 129 (2011) 1355-1361.[26] T. Manaharan, L.L. Teng, D. Appleton, et al., Antioxidant and antiglycemic potential of Peltophorum pterocarpum plant parts, Food Chem. 129 (2011) 1355-1361.

    27. [27] X. Wang, L.S. Zhang, L.L. Dong, Inhibitory effect of polysaccharides from pumpkin on advanced glycation end-products formation and aldose reductase activity, Food Chem. 130 (2012) 821-825.[27] X. Wang, L.S. Zhang, L.L. Dong, Inhibitory effect of polysaccharides from pumpkin on advanced glycation end-products formation and aldose reductase activity, Food Chem. 130 (2012) 821-825.

    28. [28] J.X. Yang, J. Guo, J.F. Yuan, In vitro antioxidant properties of rutin, LWT -Food Sci. Technol. 41 (2008) 1060-1066.[28] J.X. Yang, J. Guo, J.F. Yuan, In vitro antioxidant properties of rutin, LWT -Food Sci. Technol. 41 (2008) 1060-1066.

    29. [29] Z.H. Gao, H.B. Xu, X.J. Chen, H. Chen, Antioxidant status and mineral contents in tissues of rutin and baicalin fed rats, Life Sci. 73 (2003) 1599-1607.[29] Z.H. Gao, H.B. Xu, X.J. Chen, H. Chen, Antioxidant status and mineral contents in tissues of rutin and baicalin fed rats, Life Sci. 73 (2003) 1599-1607.

    30. [30] H.J. Heo, D.O. Kim, S.J. Choi, D.H. Shin, C.Y. Lee, Potent inhibitory effect of flavonoids in Scutellaria baicalensis on amyloid beta protein-induced neurotoxicity, J. Agric. Food Chem. 52 (2004) 4128-4132.[30] H.J. Heo, D.O. Kim, S.J. Choi, D.H. Shin, C.Y. Lee, Potent inhibitory effect of flavonoids in Scutellaria baicalensis on amyloid beta protein-induced neurotoxicity, J. Agric. Food Chem. 52 (2004) 4128-4132.

    31. [31] S.C. Ho, S.P. Wu, S.M. Lin, Y.L. Tang, Comparison of anti-glycation capacities of several herbal infusions with that of green tea, Food Chem. 122 (2010) 768-774.[31] S.C. Ho, S.P. Wu, S.M. Lin, Y.L. Tang, Comparison of anti-glycation capacities of several herbal infusions with that of green tea, Food Chem. 122 (2010) 768-774.

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  • 收稿日期:  2014-02-26
  • 网络出版日期:  2014-04-14
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