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2-苯基-4-硒唑甲酸铜(Ⅱ)配合物的合成、晶体结构和生物活性

秦毅 ,  石沛 ,  管全银 ,  施霞 ,  赵国良

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引用本文: 秦毅, 石沛, 管全银, 施霞, 赵国良. 2-苯基-4-硒唑甲酸铜(Ⅱ)配合物的合成、晶体结构和生物活性[J]. 无机化学学报, 2013, 29(9): 2013-2020. doi: 10.3969/j.issn.1001-4861.2013.00.266 shu
Citation:  QIN Yi, SHI Pei, GUAN Quan-Yin, SHI Xia, ZHAO Guo-Liang. A Copper(Ⅱ) Complex Constructed by 2-Phenyl-4-selenazole Carboxylic Acid：Synthesis, Crystal Structure and Biological Activity[J]. Chinese Journal of Inorganic Chemistry, 2013, 29(9): 2013-2020. doi: 10.3969/j.issn.1001-4861.2013.00.266 shu

2-苯基-4-硒唑甲酸铜(Ⅱ)配合物的合成、晶体结构和生物活性

  • 基金项目:

    浙江省自然科学基金(No.Y4080256)资助项目。 (No.Y4080256)

摘要: 采用溶液法合成了一种新型铜(Ⅱ)配合物[Cu2(NO3)2L(phen)2(H2O)]NO3(HL=2-苯基-4-硒唑甲酸,phen=1,10-邻菲啰啉)。用元素分析、红外光谱等表征手段确定了配合物的组成;用单晶X-射线衍射测定了配合物的晶体结构。配合物C34H24Cu2N8O12Se属于三斜晶系,空间群P1。用溴化乙锭荧光探针法研究了配合物与DNA的相互作用。分别考察了配体和配合物对五种细菌:大肠埃氏杆菌(E.coli), 表皮葡萄球菌(S.epidermidis), 草绿色链球菌(S.viridans),金黄色葡萄球菌(S. aureus),鲍曼不动杆菌(A.baumanii)的抗菌活性。同时也考察了配体和配合物对人类胰腺癌PANC-28细胞和人类肝癌HuH7细胞的体外增殖抑制作用。实验结果表明配合物具有良好的生物活性。

English

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  • 收稿日期:  2012-11-16
  • 网络出版日期:  2013-03-01
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