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钆基富勒烯磁共振成像分子影像探针的研究进展

郑俊鹏 ,  甄明明 ,  王春儒 ,  舒春英

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引用本文: 郑俊鹏, 甄明明, 王春儒, 舒春英. 钆基富勒烯磁共振成像分子影像探针的研究进展[J]. 分析化学, 2012, 40(10): 1607-1615. doi: 10.3724/SP.J.1096.2012.20380 shu
Citation:  ZHENG Jun-Peng, ZHEN Ming-Ming, WANG Chun-Ru, SHU Chun-Ying. Recent Progress of Molecular Imaging Probes Based on Gadofullerenes[J]. Chinese Journal of Analytical Chemistry, 2012, 40(10): 1607-1615. doi: 10.3724/SP.J.1096.2012.20380 shu

钆基富勒烯磁共振成像分子影像探针的研究进展

    通讯作者: 舒春英
  • 基金项目:

    本文系国家自然科学基金(Nos.21121063, 51072200) (Nos.21121063, 51072200)

    NSAF联合基金(No.11076027)资助 (No.11076027)

摘要: 含有顺磁性金属钆离子及钆团簇的内嵌金属富勒烯(如Gd@C82,Gd@C60和Gd3N@C80)及其衍生物是一类高效的MRI分子影像探针,其造影效率远优于传统钆基螯合物造影剂。重要的是,碳笼的高度稳定性保护了内嵌团簇,使之免受体内代谢物质的进攻和防止了外泄,从而大大提高了其生物安全性。同时,碳笼还是其它生物活性物质或分子影像探针的有效载体,易赋予其多功能性,从而提高疾病检测的灵敏度和准确性。本文介绍了多种钆内嵌金属富勒烯分子影像探针的研究进展,讨论了内嵌金属团簇和笼外化学修饰对其弛豫性能的影响,以及不同的功能基团对其生物相容性和动物体内分布的影响,并展望了其兼具多功能分子影像探针载体的应用前景。

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  • 收稿日期:  2012-04-11
  • 网络出版日期:  2012-06-06
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