C2-symmetric BINOL-squaramide as efficient organocatalyst for the enantioselective α-amination of 1,3-dicarbonyl compounds with dialkyl azodicarboxylates

Shi Tang Zhi-yong Wang Bin Liu Chun-E. Dong

Citation:  Shi Tang, Zhi-yong Wang, Bin Liu, Chun-E. Dong. C2-symmetric BINOL-squaramide as efficient organocatalyst for the enantioselective α-amination of 1,3-dicarbonyl compounds with dialkyl azodicarboxylates[J]. Chinese Chemical Letters, 2015, 26(6): 744-748. doi: 10.1016/j.cclet.2015.03.033 shu

C2-symmetric BINOL-squaramide as efficient organocatalyst for the enantioselective α-amination of 1,3-dicarbonyl compounds with dialkyl azodicarboxylates

    通讯作者: Chun-E. Dong,
  • 基金项目:

    We are grateful to the Fundamental Research Funds for the Central Universities (No. 2042014kf0248) for support of this research. (No. 2042014kf0248)

摘要: The asymmetric α-amination of 1,3-dicarbonyl compounds with dialkyl azodicarboxylates has been achieved by C2-symmetric BINOL-squaramide bearing multiple hydrogen bond donors to provide the desired products in excellent yields and enantioselectivities (up to 99% yield and 98% ee).

English

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  • 发布日期:  2015-04-03
  • 收稿日期:  2014-12-17
  • 网络出版日期:  2015-03-05
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