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Oxidative intramolecular coupling of 2, 3-disubstituted phenyl acrylic acids and derivatives promoted by di-tert-butylperoxide

De-Rong Ji ,  Hua Yang ,  Xiao-Jing Zhao ,  Hao Yang ,  Yang-Zhao Liu ,  Dai-Hui Liao ,  Chun Feng ,  Cheng-Gang Zhang

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Citation:  De-Rong Ji, Hua Yang, Xiao-Jing Zhao, Hao Yang, Yang-Zhao Liu, Dai-Hui Liao, Chun Feng, Cheng-Gang Zhang. Oxidative intramolecular coupling of 2, 3-disubstituted phenyl acrylic acids and derivatives promoted by di-tert-butylperoxide[J]. Chinese Chemical Letters, 2014, 25(2): 348-350. shu

Oxidative intramolecular coupling of 2, 3-disubstituted phenyl acrylic acids and derivatives promoted by di-tert-butylperoxide

    • 通讯作者: Cheng-Gang Zhang,
  • 基金项目:

    The authors are grateful to Sichuan Provincial Education Department (No. 12ZA141)  (No. 12ZA141)

    Key Laboratory of Advanced Functional Materials of Sichuan Province Higher Education System (No. KFKT2013-01)  (No. KFKT2013-01)

    Sichuan Normal University (No. XYZ2013- 14-37) for financial support. (No. XYZ2013- 14-37)

摘要: Polymethoxy-substituted phenanthrene-9-carboxylic acids or theirmethylate are key intermediates for the synthesis of tylophora alkaloids and their analogs. An intramolecular oxidative coupling reaction of unfunctionalized 2,3-disubstituted phenyl acrylic acids and derivatives promoted by di-tert-butylperoxide gave above intermediates in high yields. The mild reaction conditions and easy purification procedures of this method provide a new approach for the synthesis of phenanthrenes.

English

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  • 收稿日期:  2013-07-06
  • 网络出版日期:  2013-10-23
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