Citation: ZOU Hui, NI Xiang, PENG Sheng-Lin, OUYANG Jun, CHEN Yu, OUYANG Fang-Ping. First-Principles Study of Graphene-Based Biomolecular Sensor[J]. Acta Physico-Chimica Sinica, 2013, 29(02): 250-254. doi: 10.3866/PKU.WHXB201211141
石墨烯基生物分子传感器件的第一性原理研究
English
First-Principles Study of Graphene-Based Biomolecular Sensor
First-principles calculations were applied to design and study the electron transport behavior of a biomolecular sensor with graphene-based electrodes. It is shown that the designed biosensor is capable of distinguishing different nucleotide molecules such as cytosine, methylcytosine, and hydroxymethylcytosine. The current was seen to change by nearly one order of magnitude, while molecules passed through the device individually. The resolution capacity of the present device was primarily determined by the interactions and specific configurations of two adjacent single-stranded desoxyribonucleic acid (DNA) molecules and their specific configurations. This graphene-based biosensor was proved to be effective and efficient in detecting and distinguishing different DNA molecules, which provides a new potential method to pinpoint exactly varietal base molecules in DNAchains for the genetic information.
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Key words:
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First-principles
- / Graphene
- / Methylcytosine
- / Hydroxymethylcytosine
- / Transverse conductance
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