引用本文:
阚锦晴, 穆绍林. 伞形酮对黄嘌呤氧化酶的抑制作用研究[J]. 物理化学学报,
1997, 13(07): 650-654.
doi:
10.3866/PKU.WHXB19970716
Citation: Kan Jin-Qing, Mu Shao-Lin. Study on Inhibition of Xanthine Oxidase by Umbelliferone[J]. Acta Physico-Chimica Sinica, 1997, 13(07): 650-654. doi: 10.3866/PKU.WHXB19970716
Citation: Kan Jin-Qing, Mu Shao-Lin. Study on Inhibition of Xanthine Oxidase by Umbelliferone[J]. Acta Physico-Chimica Sinica, 1997, 13(07): 650-654. doi: 10.3866/PKU.WHXB19970716
English
Study on Inhibition of Xanthine Oxidase by Umbelliferone
Abstract:
The investigation on inhibition of xanthine oxidase by umbelliferone was carried out using a polyaniline-xanthine oxidase electrode. The experimental results indicated significant inhibition caused by umbelliferone. The apparent Michaelis-Menten constant (K'm) and the maximum rate (im) of the immobilized xanthine oxidase were both affected by umbelliferone. This indicated that umbelliferone acts as a mixed type of inhibitor of xanthine oxidase. The optimal pH of the immobilized enzyme was hardly affected by umbelliferone; The response current increases with increasing potential in the potential range 0.55~0.68V.
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Key words:
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Polyaniline
- / Xanthine oxidase
- / Umbelliferone
- / Inhibition
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