Synthesis and biological evaluation of andrographolide derivatives as potent anti-HIV agents

• Bin Wang ^a, ,
• Jing Li ^b, ,
• Wen Long Huang ^a, ,
• Hui Bin Zhang ^a, ,
• Hai Qian ^a, ,
• Yong Tang Zheng ^c,

• a Center of Drug Discovery, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China;

• b School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China;

• c Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China

• Received Date: 11 October 2010
  
• Fund Project:

  The work was supported by the National Natural Science Fundation of China (No.30772647) and the special major science and technology project of "Creation of Major New Drugs" (No.2009ZX09102-033).