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氨三乙酸、缬氨酸、亮氨酸的三元过渡金属配合物：合成和生物学应用

Mostafa M H Khalil ,  Eglal R Souaya ,  Eman H Ismail ,  Eman Rabie

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引用本文: Mostafa M H Khalil, Eglal R Souaya, Eman H Ismail, Eman Rabie. 氨三乙酸、缬氨酸、亮氨酸的三元过渡金属配合物：合成和生物学应用[J]. 无机化学学报, 2013, 29(9): 1969-1978. doi: 10.3969/j.issn.1001-4861.2013.00.319 shu
Citation:  Mostafa M H Khalil, Eglal R Souaya, Eman H Ismail, Eman Rabie. Ternary Transition Metal Complexes of Nitrilotriacetic Acid and Valine or Leucine：Synthesis and Biological Applications[J]. Chinese Journal of Inorganic Chemistry, 2013, 29(9): 1969-1978. doi: 10.3969/j.issn.1001-4861.2013.00.319 shu

氨三乙酸、缬氨酸、亮氨酸的三元过渡金属配合物：合成和生物学应用

摘要: 以氨三乙酸HNTA2-为主要配体,缬氨酸(valine)或亮氨酸(leucine)为次要配体在微酸性介质中合成了Ni(Ⅱ),Cu(Ⅱ),and Zn(Ⅱ)的三元配合物。用元素分析、热分析、FTIR,UV-Vis分光光度法,磁性测量和质谱法表征了合成的三元配合物。结果表明,三元配合物可在金属(M):氨三乙酸(HNTA):缬氨酸(valine)或亮氨酸(leucine)＝1:1:1时制得,其分子结构为[M(HNTA)(valine)(H2O)2]·1.5H2O and[M(HNTA)(leucine)(H2O)2]·1.5H2O(其中M=Ni(Ⅱ) or Cu(Ⅱ))和H2[Zn(NTA)(valine)(H2O)]H2O。标题三元过渡金属配合物为八面体对称构型。同时研究了该三元配合物对大肠杆菌,金黄色葡萄球菌,白色念珠菌,黄曲霉菌(菌株从开罗大学理学院微分析中心获得)的抗菌活性。根据推荐的知名方法用标准的抗菌和抗真菌剂进行体外测试(in vitro)以评估我们的新制备的配合物对细菌和真菌物种的生长抑制活性。

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  • 收稿日期:  2013-02-16
  • 网络出版日期:  2013-05-28
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