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2-苯基-4-硒唑甲酸铜(Ⅱ)配合物的合成、晶体结构和生物活性

秦毅 ,  石沛 ,  管全银 ,  施霞 ,  赵国良

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引用本文: 秦毅, 石沛, 管全银, 施霞, 赵国良. 2-苯基-4-硒唑甲酸铜(Ⅱ)配合物的合成、晶体结构和生物活性[J]. 无机化学学报, 2013, 29(9): 2013-2020. doi: 10.3969/j.issn.1001-4861.2013.00.266 shu
Citation:  QIN Yi, SHI Pei, GUAN Quan-Yin, SHI Xia, ZHAO Guo-Liang. A Copper(Ⅱ) Complex Constructed by 2-Phenyl-4-selenazole Carboxylic Acid：Synthesis, Crystal Structure and Biological Activity[J]. Chinese Journal of Inorganic Chemistry, 2013, 29(9): 2013-2020. doi: 10.3969/j.issn.1001-4861.2013.00.266 shu

2-苯基-4-硒唑甲酸铜(Ⅱ)配合物的合成、晶体结构和生物活性

  • 基金项目:

    浙江省自然科学基金(No.Y4080256)资助项目。 (No.Y4080256)

摘要: 采用溶液法合成了一种新型铜(Ⅱ)配合物[Cu2(NO3)2L(phen)2(H2O)]NO3(HL=2-苯基-4-硒唑甲酸,phen=1,10-邻菲啰啉)。用元素分析、红外光谱等表征手段确定了配合物的组成;用单晶X-射线衍射测定了配合物的晶体结构。配合物C34H24Cu2N8O12Se属于三斜晶系,空间群P1。用溴化乙锭荧光探针法研究了配合物与DNA的相互作用。分别考察了配体和配合物对五种细菌:大肠埃氏杆菌(E.coli), 表皮葡萄球菌(S.epidermidis), 草绿色链球菌(S.viridans),金黄色葡萄球菌(S. aureus),鲍曼不动杆菌(A.baumanii)的抗菌活性。同时也考察了配体和配合物对人类胰腺癌PANC-28细胞和人类肝癌HuH7细胞的体外增殖抑制作用。实验结果表明配合物具有良好的生物活性。

English

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    1. [1] XU Bin-He(徐兵河), SUN Yan(孙燕). Chinese J. New Drugs (Zhongguo Xinyao Zazhi), 1998,7(3):176-180[1] XU Bin-He(徐兵河), SUN Yan(孙燕). Chinese J. New Drugs (Zhongguo Xinyao Zazhi), 1998,7(3):176-180

    2. [2] Lucia L, Viera V, Jela B. Toxicology, 2006,227(1/2):1-14[2] Lucia L, Viera V, Jela B. Toxicology, 2006,227(1/2):1-14

    3. [3] Lovell M A, Xiong S, Lyubartseva G, et al. Free Radic. Biol. Med., 2009,46(11):1527-1533[3] Lovell M A, Xiong S, Lyubartseva G, et al. Free Radic. Biol. Med., 2009,46(11):1527-1533

    4. [4] Srivastava P C, Robins R K. J. Med. Chem., 1983,26(3):445-448[4] Srivastava P C, Robins R K. J. Med. Chem., 1983,26(3):445-448

    5. [5] Boritzki T J, Berry D A, Besserer J A, et al. Biochem. Pharmacol., 1985,34(7):1109-1114[5] Boritzki T J, Berry D A, Besserer J A, et al. Biochem. Pharmacol., 1985,34(7):1109-1114

    6. [6] Kumar Y, Green R, Borysko K Z, et al. J. Med. Chem., 1993, 36(3):3843-3848[6] Kumar Y, Green R, Borysko K Z, et al. J. Med. Chem., 1993, 36(3):3843-3848

    7. [7] Kumar Y, Green R, Wise D S, et al. J. Med. Chem., 1993,36 (3):3849-3852[7] Kumar Y, Green R, Wise D S, et al. J. Med. Chem., 1993,36 (3):3849-3852

    8. [8] Erkkilia K E, Odom D T, Barton J K. Chem. Rev., 1999,99 (9):2777-2796[8] Erkkilia K E, Odom D T, Barton J K. Chem. Rev., 1999,99 (9):2777-2796

    9. [9] Peng B, Chao H, Sun B, et al. J. Inorg. Biochem., 2007,101 (3):404-411[9] Peng B, Chao H, Sun B, et al. J. Inorg. Biochem., 2007,101 (3):404-411

    10. [10] Jiang Q, Xiao N, Shi P F, et al. Coord. Chem. Rev., 2007, 251(15/16):1951-1972[10] Jiang Q, Xiao N, Shi P F, et al. Coord. Chem. Rev., 2007, 251(15/16):1951-1972

    11. [11] YAO Wei(姚威), WU Bao-Yan(吴宝燕), GAO Li-Hua (高丽华), et al. Acta Phys.-Chim. Sin. (Wuli Huaxue Xuebao), 2007,23(02):237-241[11] YAO Wei(姚威), WU Bao-Yan(吴宝燕), GAO Li-Hua (高丽华), et al. Acta Phys.-Chim. Sin. (Wuli Huaxue Xuebao), 2007,23(02):237-241

    12. [12] GAO En-Jun(高恩君), DING Li-Na(丁丽娜), LIU Qi-Tao (刘祁涛), et al. Acta Phys.-Chim. Sin. (Wuli Huaxue Xuebao). 2005,21(10):1091-1095[12] GAO En-Jun(高恩君), DING Li-Na(丁丽娜), LIU Qi-Tao (刘祁涛), et al. Acta Phys.-Chim. Sin. (Wuli Huaxue Xuebao). 2005,21(10):1091-1095

    13. [13] Sigman D S. Acc. Chem. Res., 1986,19(6):180-186[13] Sigman D S. Acc. Chem. Res., 1986,19(6):180-186

    14. [14] Thomas A M, Nethaji M, Chakravarty A R. J. Inorg. Biochem., 2004,98(6):1087-1094[14] Thomas A M, Nethaji M, Chakravarty A R. J. Inorg. Biochem., 2004,98(6):1087-1094

    15. [15] Reddy P A N, Santra B K, Nethaji M, et al. J. Inorg. Biochem., 2004,98(2):377-386[15] Reddy P A N, Santra B K, Nethaji M, et al. J. Inorg. Biochem., 2004,98(2):377-386

    16. [16] Ruiz E, Tang X J, Li Y J, et al. J. Cryst. Spectr. Res., 1993, 23(10):791-794[16] Ruiz E, Tang X J, Li Y J, et al. J. Cryst. Spectr. Res., 1993, 23(10):791-794

    17. [17] Muir M M, Gomez G M, Cadiz M E, et al. Inorg. Chim. Acta, 1990,168(1):47-57[17] Muir M M, Gomez G M, Cadiz M E, et al. Inorg. Chim. Acta, 1990,168(1):47-57

    18. [18] Barkigia K M, Renner M W, Senge M O, et al. J. Phys. Chem. B, 2004,108(7):2173-2180[18] Barkigia K M, Renner M W, Senge M O, et al. J. Phys. Chem. B, 2004,108(7):2173-2180

    19. [19] Zhou A J, Zheng S L, Fang Y, et al. Inorg. Chem., 2005,44 (13):4457-4459[19] Zhou A J, Zheng S L, Fang Y, et al. Inorg. Chem., 2005,44 (13):4457-4459

    20. [20] Tan C K, Wang J, Leng J D, et al. Eur. J. Inorg. Chem., 2008(5):771-778[20] Tan C K, Wang J, Leng J D, et al. Eur. J. Inorg. Chem., 2008(5):771-778

    21. [21] ZHAO Guo-Liang(赵国良), SHI Xia(施霞), ZHANG Jun-Ping(张均平), et al. Scientia Sinica: Chimica(Zhongguo Kexue: Chemistry), 2010,40(10):1525-1535[21] ZHAO Guo-Liang(赵国良), SHI Xia(施霞), ZHANG Jun-Ping(张均平), et al. Scientia Sinica: Chimica(Zhongguo Kexue: Chemistry), 2010,40(10):1525-1535

    22. [22] ZHAO Guo-Liang(赵国良), SHEN Jin-Bei(沈金杯), SHI Xia (施霞), et al. Chinese J. Inorg. Chem. (Wuji Huaxue Xuebao), 2012,28(5):959-964[22] ZHAO Guo-Liang(赵国良), SHEN Jin-Bei(沈金杯), SHI Xia (施霞), et al. Chinese J. Inorg. Chem. (Wuji Huaxue Xuebao), 2012,28(5):959-964

    23. [23] Kamal A, Mallareddy A, Suresh P, et al. Eur. J. Med. Chem., 2012,47:530545[23] Kamal A, Mallareddy A, Suresh P, et al. Eur. J. Med. Chem., 2012,47:530545

    24. [24] Sheldrick G M. SADABS, Program for Empirical Absorption Correction of Area detector Data, University of Göttingen, Germany, 1997.[24] Sheldrick G M. SADABS, Program for Empirical Absorption Correction of Area detector Data, University of Göttingen, Germany, 1997.

    25. [25] Sheldrick G M. SHELXS-97, Program for Crystal Structure Solution. University of Göttingen, Germany, 1997.[25] Sheldrick G M. SHELXS-97, Program for Crystal Structure Solution. University of Göttingen, Germany, 1997.

    26. [26] Sheldrick G M. SHELXL-97, Program for Crystal Structure Refinement. University of Göttingen, Germany, 1997.[26] Sheldrick G M. SHELXL-97, Program for Crystal Structure Refinement. University of Göttingen, Germany, 1997.

    27. [27] Gao H L, Yi L, Zhao B, et al. Inorg. Chem., 2006,45(15): 5980-5988[27] Gao H L, Yi L, Zhao B, et al. Inorg. Chem., 2006,45(15): 5980-5988

    28. [28] Singh U P, Tyagi S, Sharma C L, et al. J. Chem. Soc., Dalton Trans., 2002,23:4464-4470[28] Singh U P, Tyagi S, Sharma C L, et al. J. Chem. Soc., Dalton Trans., 2002,23:4464-4470

    29. [29] Nakamoto K(中本一雄), Translated by HUANG De-Ru (黄德如), WANG Ren-Qing(汪仁庆). Infrared and Raman Spectra of Inorganic and Coordination Compounds. 3rd Ed. (无机和配位化合物的红外和拉曼光谱. 3版). Beijing: Chemical Industry Press, 1986.[29] Nakamoto K(中本一雄), Translated by HUANG De-Ru (黄德如), WANG Ren-Qing(汪仁庆). Infrared and Raman Spectra of Inorganic and Coordination Compounds. 3rd Ed. (无机和配位化合物的红外和拉曼光谱. 3版). Beijing: Chemical Industry Press, 1986.

    30. [30] Casellato U, Tamburini S, Tomasin P, et al. Inorg. Chim. Acta, 1997,262(2):117-121[30] Casellato U, Tamburini S, Tomasin P, et al. Inorg. Chim. Acta, 1997,262(2):117-121

    31. [31] Min D W, Cho B Y, Lee S W. Inorg. Chim. Acta, 2006,359 (2)577-584[31] Min D W, Cho B Y, Lee S W. Inorg. Chim. Acta, 2006,359 (2)577-584

    32. [32] Bünzli J C G, Charbonnière L J, Ziessel R F. J. Chem. Soc., Dalton Trans., 2000,12:1917-1923[32] Bünzli J C G, Charbonnière L J, Ziessel R F. J. Chem. Soc., Dalton Trans., 2000,12:1917-1923

    33. [33] Hubrich M, Peukert M, Seichter W, et al. Polyhedron, 2010, 29(7):1854-1862[33] Hubrich M, Peukert M, Seichter W, et al. Polyhedron, 2010, 29(7):1854-1862

    34. [34] Lakowicz J R, Weber G. Biochemistry, 1973,12(21):4161-4170[34] Lakowicz J R, Weber G. Biochemistry, 1973,12(21):4161-4170

    35. [35] Liu J, Zhang T X, Lu T B, et al. J. Inorg. Biochem., 2002,91(1):269-276[35] Liu J, Zhang T X, Lu T B, et al. J. Inorg. Biochem., 2002,91(1):269-276

    36. [36] Baguley B C, Bret M L. Biochemistry, 1984,23(5):937-943[36] Baguley B C, Bret M L. Biochemistry, 1984,23(5):937-943

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  • 收稿日期:  2012-11-16
  • 网络出版日期:  2013-03-01
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