基于金银合金薄膜的波长检测型表面等离子体共振传感器

引用本文: 张喆, 刘杰, 逯丹凤, 祁志美. 基于金银合金薄膜的波长检测型表面等离子体共振传感器[J]. 物理化学学报, 2014, 30(9): 1771-1777. doi: 10.3866/PKU.WHXB201407071 shu

Citation: ZHANG Zhe, LIU Jie, LU Dan-Feng, QI Zhi-Mei. Wavelength-Interrogated Surface Plasmon Resonance Sensor Based on Au-Ag Alloy Film[J]. Acta Physico-Chimica Sinica, 2014, 30(9): 1771-1777. doi: 10.3866/PKU.WHXB201407071 shu

基于金银合金薄膜的波长检测型表面等离子体共振传感器

张喆 ^1, ,
刘杰 ^1, ,
逯丹凤 ^2, ,
祁志美 ^2,

基金项目:
中央高校基本科研业务费（2014JBM026）资助项目

摘要:

从实验和理论两方面详细研究了金银合金膜表面等离子体共振（SPR）传感器在可见光波段的敏感特性. 实验方面，通过在玻璃基底上溅射50 nm厚的金银合金薄膜制备了一种新型的SPR传感芯片，并且自行搭建了基于Kretschmann 结构的波长检测型SPR传感器测试平台. 利用不同浓度的氯化钠（NaCl）水溶液和浓度为10 μmol·L^-1的牛血清蛋白（BSA）水溶液分别作为折射率样品和分子吸附样品，研究了传感器的折射率灵敏度和吸附灵敏度，并与金膜和银膜SPR传感器进行了对比研究. 结果表明，对于折射率灵敏度的测试，金银合金膜SPR传感器大幅高于金膜SPR传感器，略低于银膜SPR传感器；而对于吸附敏感的研究，金银合金膜SPR传感器的灵敏度与银膜SPR传感器相近，是金膜SPR传感器的3倍. 理论方面，利用菲涅尔公式和等效折射率计算公式仿真计算了这三种薄膜结构的SPR传感器的灵敏度和精确度，结果指出金银合金膜SPR传感器的灵敏度与银膜SPR传感器接近，是常规金膜SPR传感器的2.31倍，而半高峰宽仅为金膜和银膜SPR传感器的1.36 倍. 在稳定性方面，金银合金膜SPR传感器与金膜SPR传感器均具有良好的化学稳定性，而银膜SPR传感器较易氧化，使用寿命低，不常被采用. 综上，金银合金膜在改善传感器灵敏度的同时，不会降低精度，是一种高灵敏、低成本、良好稳定性的SPR传感器敏感材料.

关键词:

English

Wavelength-Interrogated Surface Plasmon Resonance Sensor Based on Au-Ag Alloy Film

1.
1. Department of Biomedical Engineering, School of Computer and Information Technology, Beijing Jiaotong University, Beijing 100044, P. R. China;
2. State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, P. R. China
Received Date: 13 May 2014
Available Online: 29 August 2014
Fund Project:
中央高校基本科研业务费（2014JBM026）资助项目

Abstract:

An Au-Ag alloy film surface plasmon resonance (SPR) sensor was studied experimentally and theoretically. SPR chips were prepared by sputtering a glass surface with a 50-nm-thick Au-Ag alloy film, and experiments were carried out with the wavelength-interrogated SPR sensor using the Kretschmann configuration. Aqueous sodium chloride and bovine serum albumin solutions were used to study the refractive index and adsorption sensitivities of the sensor. The results were compared with those obtained using Au film and Ag film SPR sensors. The refractive index sensitivity of the Au-Ag alloy film SPR sensor is higher than that of the Au film SPR sensor, but lower than that of the Ag film SPR sensor. The adsorption sensitivity of the Au- Ag alloy film SPR sensor is similar to that of the Ag film SPR, and three times of the Au film SPR sensor. Theoretical studies showed that that the sensitivity of the Au-Ag alloy film SPR is close to that of the Ag film SPR sensor, and 2.31 times of the Au film SPR sensor. The full width at half maximum of the Au-Ag film sensor is only 0.36 times of the Au or Ag film SPR sensors. The Au-Ag alloy film and Au film SPR sensors are chemically stable, but the Ag film SPR sensor is easily oxidized, so it is not often used. These results show that an Au-Ag alloy film can improve the sensitivity of the sensor, while retaining the accuracy. Au-Ag films could therefore be used as high-sensitivity, low cost, and stable SPR-sensitive materials.

Key words:

1. [1]
  
  (1) Homola, J. Chemical Reviews 2008, 108, 462. doi: 10.1021/cr068107d
  (1) Homola, J. Chemical Reviews 2008, 108, 462. doi: 10.1021/cr068107d
2. [2]
  (2) Zeng, S.; Baillargeat, D.; Ho, H. P.; Yong, K. T. Chemical Society Reviews 2014, 43, 3426. doi: 10.1039/c3cs60479a(2) Zeng, S.; Baillargeat, D.; Ho, H. P.; Yong, K. T. Chemical Society Reviews 2014, 43, 3426. doi: 10.1039/c3cs60479a
3. [3]
  (3) Zijlstra, P.; Paulo, P. M.; Orrit, M. Nature Nanotechnology 2012, 7, 379. doi: 10.1038/nnano.2012.51(3) Zijlstra, P.; Paulo, P. M.; Orrit, M. Nature Nanotechnology 2012, 7, 379. doi: 10.1038/nnano.2012.51
4. [4]
  (4) Zhang, Z.; Lu, D. F.; Qi, Z. M. Acta Phys. -Chim. Sin. 2013, 29, 867. [张喆, 逯丹凤, 祁志美. 物理化学学报, 2013, 29, 867.] doi: 10.3866/PKU.WHXB201302222(4) Zhang, Z.; Lu, D. F.; Qi, Z. M. Acta Phys. -Chim. Sin. 2013, 29, 867. [张喆, 逯丹凤, 祁志美. 物理化学学报, 2013, 29, 867.] doi: 10.3866/PKU.WHXB201302222
5. [5]
  (5) Shalabney, A.; Abdulhalim, I. Optics Letters 2012, 37, 1175. doi: 10.1364/OL.37.001175(5) Shalabney, A.; Abdulhalim, I. Optics Letters 2012, 37, 1175. doi: 10.1364/OL.37.001175
6. [6]
  (6) Abbas, A.; Linman, M. J.; Cheng, Q. Biosensors and Bioelectronics 2011, 26, 1815. doi: 10.1016/j.bios.2010.09.030(6) Abbas, A.; Linman, M. J.; Cheng, Q. Biosensors and Bioelectronics 2011, 26, 1815. doi: 10.1016/j.bios.2010.09.030
7. [7]
  (7) Srivastava, S. K.; Verma, R.; Gupta, B. D. Sensors and Actuators B: Chemical 2011, 153, 194. doi: 10.1016/j.snb.2010.10.038(7) Srivastava, S. K.; Verma, R.; Gupta, B. D. Sensors and Actuators B: Chemical 2011, 153, 194. doi: 10.1016/j.snb.2010.10.038
8. [8]
  (8) Linman, M. J.; Abbas, A.; Cheng, Q. Analyst 2010, 135, 2759. doi: 10.1039/c0an00466a(8) Linman, M. J.; Abbas, A.; Cheng, Q. Analyst 2010, 135, 2759. doi: 10.1039/c0an00466a
9. [9]
  (9) Mitchell, J. Sensors 2010, 10, 7323. doi: 10.3390/s100807323(9) Mitchell, J. Sensors 2010, 10, 7323. doi: 10.3390/s100807323
10. [10]
  (10) Hodnik, V.; Anderluh, G. Sensors 2009, 9, 1339.(10) Hodnik, V.; Anderluh, G. Sensors 2009, 9, 1339.
11. [11]
  (11) Zhai, P.; Guo, J.; Xiang, J.; Zhou, F. The Journal of Physical Chemistry C 2007, 111, 981. doi: 10.1021/jp065525d(11) Zhai, P.; Guo, J.; Xiang, J.; Zhou, F. The Journal of Physical Chemistry C 2007, 111, 981. doi: 10.1021/jp065525d
12. [12]
  (12) Frischeisen, J.; Mayr, C.; Reinke, N. A.; Nowy, S.; Br?tting, W. Optics Express 2008, 16, 18426. doi: 10.1364/OE.16.018426(12) Frischeisen, J.; Mayr, C.; Reinke, N. A.; Nowy, S.; Br?tting, W. Optics Express 2008, 16, 18426. doi: 10.1364/OE.16.018426
13. [13]
  (13) Mazumdar, S. D.; Hartmann, M.; Kämpfer, P.; Keusgen, M. Biosensors and Bioelectronics 2007, 22, 2040. doi: 10.1016/j.bios.2006.09.004(13) Mazumdar, S. D.; Hartmann, M.; Kämpfer, P.; Keusgen, M. Biosensors and Bioelectronics 2007, 22, 2040. doi: 10.1016/j.bios.2006.09.004
14. [14]
  (14) Qi, Z. M.; Xia, S.;Wei, M.; Matsuda, H.; Zhou, H. Applied Optics 2007, 46, 7963. doi: 10.1364/AO.46.007963(14) Qi, Z. M.; Xia, S.;Wei, M.; Matsuda, H.; Zhou, H. Applied Optics 2007, 46, 7963. doi: 10.1364/AO.46.007963
15. [15]
  (15) Shankaran, D. R.; bi, K. V.; Miura, N. Sensors and Actuators B: Chemical 2007, 121, 158. doi: 10.1016/j.snb.2006.09.014(15) Shankaran, D. R.; bi, K. V.; Miura, N. Sensors and Actuators B: Chemical 2007, 121, 158. doi: 10.1016/j.snb.2006.09.014
16. [16]
  (16) Hao, P.;Wu, Y. H.; Zhang, P. Acta Phys. Sin. 2010, 59, 6532. [郝鹏, 吴一辉, 张平. 物理学报, 2010, 59, 6532.](16) Hao, P.;Wu, Y. H.; Zhang, P. Acta Phys. Sin. 2010, 59, 6532. [郝鹏, 吴一辉, 张平. 物理学报, 2010, 59, 6532.]
17. [17]
  (17) Alleyne, C. J.; Kirk, A. G.; McPhedran, R. C.; Nicorovici, N. A. P.; Maystre, D. Optics Express 2007, 15, 8163. doi: 10.1364/OE.15.008163(17) Alleyne, C. J.; Kirk, A. G.; McPhedran, R. C.; Nicorovici, N. A. P.; Maystre, D. Optics Express 2007, 15, 8163. doi: 10.1364/OE.15.008163
18. [18]
  (18) Manickam, G.; Gandhiraman, R.; Vijayaraghavan, R. K.; Kerr, L.; Doyle, C.;Williams, D. E.; Daniels, S. Analyst 2012, 137, 5265. doi: 10.1039/c2an35826c(18) Manickam, G.; Gandhiraman, R.; Vijayaraghavan, R. K.; Kerr, L.; Doyle, C.;Williams, D. E.; Daniels, S. Analyst 2012, 137, 5265. doi: 10.1039/c2an35826c
19. [19]
  (19) http://www.iri.cnrs.fr/IMG/pdf/SPR.pdf (accessed Mar 20, 2014).(19) http://www.iri.cnrs.fr/IMG/pdf/SPR.pdf (accessed Mar 20, 2014).
20. [20]
  (20) Zhang, Z.; Liu, Q.; Qi, Z. M. Acta Phys. Sin. 2013, 62, 060703. [张喆, 柳倩, 祁志美. 物理学报, 2013, 62, 060703.](20) Zhang, Z.; Liu, Q.; Qi, Z. M. Acta Phys. Sin. 2013, 62, 060703. [张喆, 柳倩, 祁志美. 物理学报, 2013, 62, 060703.]
21. [21]
  (21) Zhang, Y.; Gao, G.; Qian, Q.; Cui, D. Nanoscale Research Letters 2012, 7, 475. doi: 10.1186/1556-276X-7-475(21) Zhang, Y.; Gao, G.; Qian, Q.; Cui, D. Nanoscale Research Letters 2012, 7, 475. doi: 10.1186/1556-276X-7-475
22. [22]
  (22) http://www.topac.com/salinity_brix.html (accessed May 12, 2014).(22) http://www.topac.com/salinity_brix.html (accessed May 12, 2014).
23. [23]
  (23) http://en.wikipedia.org/wiki/Fresnel_equations (accessed May 12, 2014).(23) http://en.wikipedia.org/wiki/Fresnel_equations (accessed May 12, 2014).
24. [24]
  (24) Wehmeyer, J. L.; Synowicki, R.; Bizios, R.; García, C. D. Mater. Sci. Eng. C Mater. Biol. Appl. 2010, 30, 277. doi: 10.1016/j.msec.2009.11.002(24) Wehmeyer, J. L.; Synowicki, R.; Bizios, R.; García, C. D. Mater. Sci. Eng. C Mater. Biol. Appl. 2010, 30, 277. doi: 10.1016/j.msec.2009.11.002
25. [25]
  (25) Chen, H.; Kim, Y. S.; Lee, J.; Yoon, S. J.; Lim, D. S.; Choi, H. J.; Koh, K. Sensors 2007, 7, 2263. doi: 10.3390/s7102263
  (25) Chen, H.; Kim, Y. S.; Lee, J.; Yoon, S. J.; Lim, D. S.; Choi, H. J.; Koh, K. Sensors 2007, 7, 2263. doi: 10.3390/s7102263

扫一扫看文章

计量

PDF下载量: 536
文章访问数: 786
HTML全文浏览量: 29

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

基于金银合金薄膜的波长检测型表面等离子体共振传感器

English

Wavelength-Interrogated Surface Plasmon Resonance Sensor Based on Au-Ag Alloy Film

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

基于金银合金薄膜的波长检测型表面等离子体共振传感器

English

Wavelength-Interrogated Surface Plasmon Resonance Sensor Based on Au-Ag Alloy Film

CCS Chemistry：嵌段共聚物自组装成 “三明治”二维有机材料，实现纳米级压力传感功能

CCS Chemistry：颜徐州、鲍哲南： 你的皮肤可能是一片SPMs

CCS Chemistry：工作高效不疲劳，只须让催化剂动起来

CCS Chemistry：静电组装导向聚合- 聚电解质纳米凝胶量化制备新策略

CCS Chemistry：金黄色葡萄球菌醛基脱氢酶是如何识别特异性底物的？

计量

文章相关

通讯作者: 陈斌, bchen63@163.com

中国化学会秘书处

CCS Chemistry：颜徐州、鲍哲南：你的皮肤可能是一片SPMs