引用本文:
侯廷军, 安钰, 廖宁, 茹炳根, 徐筱杰. 金属硫蛋白聚合中阳离子作用机制的研究[J]. 物理化学学报,
2000, 16(04): 356-361.
doi:
10.3866/PKU.WHXB20000412
Citation: Hou Ting-Jun, An Yu, Liao Ning, Ru Bing-Gen, Xu Xiao-Jie. Theoretic Studies on the Mechanism of Cations in Metallothioneins Polymerization[J]. Acta Physico-Chimica Sinica, 2000, 16(04): 356-361. doi: 10.3866/PKU.WHXB20000412
Citation: Hou Ting-Jun, An Yu, Liao Ning, Ru Bing-Gen, Xu Xiao-Jie. Theoretic Studies on the Mechanism of Cations in Metallothioneins Polymerization[J]. Acta Physico-Chimica Sinica, 2000, 16(04): 356-361. doi: 10.3866/PKU.WHXB20000412
English
Theoretic Studies on the Mechanism of Cations in Metallothioneins Polymerization
Abstract:
It has been proven by experiments that cations play a very important role in metallothioneins polymerization. In this paper, three kinds of metallothioneines including MT-Ⅱfrom rat liver, MT-Ⅰand MT-Ⅱfrom rabbit have been investigated. From the analyses of electrostatic potential, two binding sites of cations can be determined: The first one is located between the dimer interface; the other one is located in the negative electrostatic potential hole. The binding capacity between two monomers in a dimer can be regulated by these cations to some extent.
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Key words:
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Metallothioneines
- / Electrostatic potential
- / Negative electrostatic hole
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