引用本文:
张志坚, 邝代治, 张复兴, 庾江喜, 蒋伍玖. 三(2-甲基-2-苯基)丙基锡(Ⅳ)三氯乙酸酯的合成、结构和生物活性[J]. 应用化学,
2014, 31(9): 1058-1062.
doi:
10.3724/SP.J.1095.2014.30517
Citation: ZHANG Zhijian, KUANG Daizhi, ZHANG Fuxing, YU Jiangxi, JIANG Wujiu. Synthesis,Crystal Structure and Biological Activities of the Tris(2-methyl-2-phenyl) propyl Tin Trichloroacetic Acid Ester[J]. Chinese Journal of Applied Chemistry, 2014, 31(9): 1058-1062. doi: 10.3724/SP.J.1095.2014.30517
Citation: ZHANG Zhijian, KUANG Daizhi, ZHANG Fuxing, YU Jiangxi, JIANG Wujiu. Synthesis,Crystal Structure and Biological Activities of the Tris(2-methyl-2-phenyl) propyl Tin Trichloroacetic Acid Ester[J]. Chinese Journal of Applied Chemistry, 2014, 31(9): 1058-1062. doi: 10.3724/SP.J.1095.2014.30517
三(2-甲基-2-苯基)丙基锡(Ⅳ)三氯乙酸酯的合成、结构和生物活性
摘要:
三氯乙酸与氧化双[三(2-甲基-2-苯基)丙基锡]反应,合成了新配合物三(2-甲基-2-苯基)丙基锡三氯乙酸酯(CCDC:932139),经元素分析、1H NMR和IR等技术手段表征其组成和结构,通过X射线衍射方法测定了化合物的晶体结构。该化合物晶体学参数:单斜晶系,空间群为P21/n,晶胞参数:a=1.1186(4)nm,b=1.8366(7)nm,c=1.6020(6)nm,α=90°,β=91.316(7)°,γ=90°,V=3.2902(19)nm3,Z=4,Dc=1.374 g/cm3,μ(MoKα)=1.046 mm-1,F(000)=1392,R1=0.0589,wR2=0.1619;中心锡原子呈四配位畸变四面体构型。生物活性测试结果表明,标题配合物对5种肿瘤细胞株系HT-29、HepG-2、MCF-7、KB和A549均具有较好的体外抑制活性,并且具有选择性的抑菌活性。
English
Synthesis,Crystal Structure and Biological Activities of the Tris(2-methyl-2-phenyl) propyl Tin Trichloroacetic Acid Ester
Abstract:
The title complex, tris(2-methyl-2-phenyl) propyl tin trichloroacetic acid ester(CCDC:932139), was synthesized by the reaction of bis[tris(2-methyl-2-phenyl) propyl]tin oxide with trichloroacetic acid and characterized by IR, 1H NMR spectroscopy and elemental analysis, respectively. The crystal structure was determined by X-ray diffraction to be monoclinic with a P21/n space group with a=1.1186(4) nm, b=1.8366(7) nm, c=1.6020(6) nm, α=90°, β=91.316(10) °, γ=90°, V=3.2902(19) nm3, Z=4, Dc=1.374 g/cm3, μ(MoKα)=1.046 mm-1, F(000)=1392, and R1=0.0589, wR2=0.1619. The crystal structure shows that the central Sn atom is four-coordinated to assume a distorted tetrahedral configuration. Bioassay results show that the complex displays good in vitro antitumor activities against five human tumor cell lines, HT-29, HepG-2, MCF-7, KB and A549, and has selective antibacterial property.
-
-
扫一扫看文章
计量
- PDF下载量: 0
- 文章访问数: 433
- HTML全文浏览量: 22
下载:
