引用本文:
刘举, 敬春艳, 王洋, 滕鹏飞, 徐嘉瞳, 徐利锋. 新型3,6-二芳基吡唑并[1,5-a]嘧啶类化合物的合成[J]. 应用化学,
2013, 30(12): 1494-1496.
doi:
10.3724/SP.J.1095.2013.20574
Citation: LIU Ju, JING Chunyan, WANG Yang, TENG Pengfei, XU Jiatong, XU Lifeng. Synthesis of 3,6-Diarylpyrazolo[1,5-a]pyrimidines[J]. Chinese Journal of Applied Chemistry, 2013, 30(12): 1494-1496. doi: 10.3724/SP.J.1095.2013.20574
Citation: LIU Ju, JING Chunyan, WANG Yang, TENG Pengfei, XU Jiatong, XU Lifeng. Synthesis of 3,6-Diarylpyrazolo[1,5-a]pyrimidines[J]. Chinese Journal of Applied Chemistry, 2013, 30(12): 1494-1496. doi: 10.3724/SP.J.1095.2013.20574
新型3,6-二芳基吡唑并[1,5-a]嘧啶类化合物的合成
摘要:
以2-甲基-6-苯基-3-(2,4-二氯苯基)-5,7-二羟基吡唑并[1,5-a]嘧啶为原料,经三氯氧磷氯代得到2-甲基-6-苯基-3-(2,4-二氯苯基)-5,7-二氯吡唑并[1,5-a]嘧啶,氯代物再与胺类化合物经取代反应氨化得到12个未见文献报道的7-取代-3,6-二芳基取代吡唑并[1,5-a]嘧啶类衍生物。目标化合物结构经红外光谱、核磁共振氢谱、元素分析及单晶X射线衍射法表征。
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关键词:
- 吡唑并[1,5-a]嘧啶
- / 氯代反应
- / 氨化反应
- / 晶体结构
English
Synthesis of 3,6-Diarylpyrazolo[1,5-a]pyrimidines
Abstract:
Twelve new 7-substituted-3,6-diarylpyrazolo[1,5-a]pyrimidines were synthesized by the aminizations of the derivatives of 5,7-dichloro-3-(2,4-dichlorophenyl)-2-methyl-6-phenylpyrazolo[1,5-a]pyrimidine. These derivatives were prepared by the reaction of 3-(2,4-dichlorophenyl)-2-methyl-6-phenylpyrazolo[1,5-a]pyrimidine-5,7-diol and phosphorus oxychloride. The products were characterized by IR,1H NMR,elemental analysis and single crystal X-ray diffraction analysis.
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Key words:
- pyrazolo[1,5-a]pyrimidine
- / chlorination
- / aminization
- / crystal structure
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