引用本文:
郭文彦, 赵明刚, 郝爱友. 低取代度两亲性β-环糊精及其水相中纳米球的制备[J]. 应用化学,
2013, 30(3): 260-264.
doi:
10.3724/SP.J.1095.2013.20164
Citation: GUO Wenyan, ZHAO Minggang, HAO Aiyou. Synthesis of Amphiphilic β-Cyclodextrins and Their Nanospheres in Water[J]. Chinese Journal of Applied Chemistry, 2013, 30(3): 260-264. doi: 10.3724/SP.J.1095.2013.20164
Citation: GUO Wenyan, ZHAO Minggang, HAO Aiyou. Synthesis of Amphiphilic β-Cyclodextrins and Their Nanospheres in Water[J]. Chinese Journal of Applied Chemistry, 2013, 30(3): 260-264. doi: 10.3724/SP.J.1095.2013.20164
低取代度两亲性β-环糊精及其水相中纳米球的制备
摘要:
将2-O-(2-羟丙基)-β-环糊精与十二烷基、十四烷基、十六烷基和十八烷基缩水甘油醚在吡啶中反应,合成了4个低取代度的两亲性β-环糊精衍生物(平均取代度分别为1.87、1.95、2.14和1.80)。将上述4个化合物分散于水中自组装成可稳定2~3周的纳米球,并且均呈现出较好的分散度和均匀性。
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关键词:
- 两亲性
- / O-(羟丙基)-β-环糊精
- / 缩水甘油醚
- / 纳米球
English
Synthesis of Amphiphilic β-Cyclodextrins and Their Nanospheres in Water
Abstract:
Four amphiphilic bifunctionalized β-cyclodextrin derivatives with low degree of substitution(DS) were conveniently synthesized via the reaction of 2-O-(2-hydroxypropyl)-β-cyclodextrin with Lauryl glycidol ether,tetradecyl glycidol ether,hexadecyl glycidol ether and octadecyl glycidol ether in pyridine,respectively.The four amphiphilic β-CD derivatives(DS 1.87,1.95,2.14 and 1.80,respectively) could self-assemble in water to form stable nanospheres with improved dispersion degree and uniformity up to 2~3 weeks.
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Key words:
- amphiphilic
- / O-(hydroxypropyl)-β-cyclodextrin
- / glycidol ether
- / nanospheres
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