引用本文:
张慧辰, 陈晓军, 王丽侠, 赵震, 林芳芹, 关士友. 1-氮杂环[2.2.2]辛烷的高效合成[J]. 应用化学,
2012, 29(12): 1468-1470.
doi:
10.3724/SP.J.1095.2012.20014
Citation: ZHANG Huichen, CHEN Xiaojun, WANG Lixia, ZHAO Zhen, LIN Fangqin, GUAN Shiyou. High Efficient Synthesis of 1-Azabicyclo[2.2.2] octane[J]. Chinese Journal of Applied Chemistry, 2012, 29(12): 1468-1470. doi: 10.3724/SP.J.1095.2012.20014
Citation: ZHANG Huichen, CHEN Xiaojun, WANG Lixia, ZHAO Zhen, LIN Fangqin, GUAN Shiyou. High Efficient Synthesis of 1-Azabicyclo[2.2.2] octane[J]. Chinese Journal of Applied Chemistry, 2012, 29(12): 1468-1470. doi: 10.3724/SP.J.1095.2012.20014
1-氮杂环[2.2.2]辛烷的高效合成
摘要:
将4-(2-羟乙基)哌啶蒸汽在425℃下通过CNM-3型固体酸催化剂进行分子内脱水反应,一步合成了目的产物1-氮杂环[2.2.2]辛烷(奎宁环),4 h内25 g 4-(2-羟乙基)哌啶蒸汽单程收率可达76.8%,最高收率84.3%。该方法原料易得,适合于奎宁环的工业化制备。
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关键词:
- 氮杂环[2.2.2]辛烷
- / 奎宁环
- / 高效合成
- / (羟乙基)哌啶
- / 固体酸催化剂
English
High Efficient Synthesis of 1-Azabicyclo[2.2.2] octane
Abstract:
1-Azabicyclo[2.2.2]octane(quinuclidine) was obtained via the direct intramolecular dehydration reaction of 4-(2-hydroxyethyl) piperidine vapor in presence of CNM-3,a solid acidic catalyst.The yield of quinuclidine can reach 76.8% at 425℃ for 4 h with the highest yield up to 84.3%.Due to the easy accessible of the precursors,the established method is believed to be promising for the scale-up of quinuclidine.
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