引用本文:
陆鸿飞, 张亮泽, 武鼎铭, 穆维宁, 周君涛. 6氯-8-烃-基-9芳-基嘌呤类化合物的合成[J]. 应用化学,
2011, 28(7): 747-752.
doi:
10.3724/SP.J.1095.2011.00496
Citation: LI Hongfei, ZHANG Liangze, WU Dingming, MU Weining, ZHOU Juntao. Synthesis of 6-Chlorin-8-alkyl-9-aryl-purine Derivatives[J]. Chinese Journal of Applied Chemistry, 2011, 28(7): 747-752. doi: 10.3724/SP.J.1095.2011.00496
Citation: LI Hongfei, ZHANG Liangze, WU Dingming, MU Weining, ZHOU Juntao. Synthesis of 6-Chlorin-8-alkyl-9-aryl-purine Derivatives[J]. Chinese Journal of Applied Chemistry, 2011, 28(7): 747-752. doi: 10.3724/SP.J.1095.2011.00496
6氯-8-烃-基-9芳-基嘌呤类化合物的合成
English
Synthesis of 6-Chlorin-8-alkyl-9-aryl-purine Derivatives
Abstract:
Using 4,6-dichlorin-5-amino-pyrimidine as a starting material,a serials of 6-chlorin-8-alkyl-9-aryl-purine derivatives have been designed and synthesized via N-alkylation,condensation and chloridization.All synthesized compounds were confirmed by elemental analysis,MS and 1H NMR techniques.The effects of catalyst on N-alkylation,the amounts of polyphosphoric acid(PPA) on condensation,the microwave heating process on chloridization were investigated.
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Key words:
- purine derivatives
- / N-alkylation
- / condensation
- / chloridization
- / synthesis
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